AI Article Synopsis
- The study highlights the global threat of amphetamines, not just to humans but also to domestic animals, exemplified by a case of a cat suffering from both amphetamine and methamphetamine intoxication.
- Toxicological analysis was performed on various biological samples from the cat, revealing significant concentrations of these substances, as well as other drugs like diazepam.
- The findings emphasize the urgent need to raise awareness about the risks of psychoactive substance poisoning in pets and the necessity for further research on how these drugs affect animals, especially given the potential health implications.
Article Abstract
Stimulants belonging to the amphetamine group nowadays pose an undeniable worldwide threat to the life and health of users. Intoxications of domestic animals also occur, which can either be accidental or related to intentional human action. This study presents the first ever reported case of a simultaneous amphetamine and methamphetamine intoxication of a cat, along with the results of toxicological studies. Blood, urine, vitreous humor and liver were collected during the cat's autopsy and analyzed by UHPLC─QqQ─MS/MS. The sample preparation technique was based on one-step precipitation of proteins with cold acetonitrile. The determined amphetamine concentrations in the collected biological materials were 93.4 ng/mL in blood, 496.6 ng/mL in urine, 589.2 ng/mL in the vitreous humor and 291.2 ng/g in liver, respectively. Methamphetamine concentrations were 45.5 ng/mL in blood, 263.1 ng/mL in urine, 351.2 ng/mL in vitreous humor, and 97.7 ng/g in liver. Other substances were also found in the biological material, i.e., diazepam, oxazepam and nordiazepam. Cases of intentional or accidental poisoning of pets with psychoactive substances are a serious problem, carrying the risk to the health and life of the animal. Therefore, it is important to increase awareness of the high risk of poisoning of domestic animals, as well as to learn about the incompletely understood mechanisms of pharmacokinetics of various drugs in animals, including cats.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781533 | PMC |
| http://dx.doi.org/10.3390/toxics10120749 | DOI Listing |
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