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Optimization of Clozapine Treatment: Study of Variables Affecting Response in Uruguayan Patients With Schizophrenia.
J Clin Psychopharmacol
December 2024
Human Molecular Genetics Laboratory, Institut Pasteur de Montevideo, Montevideo, Uruguay.
Purpose/background: Clozapine is the recommended drug for treatment-resistant schizophrenia. Drug response could be affected by numerous factors such as age, sex, body mass index, co-medication, consumption of xanthine-containing beverages, smoking, and genetic variants of the enzymes involved in clozapine metabolism (CYP1A2, CYP3A4, and, to a lesser extent, CYP2C19 and CYP2D6). This study evaluated genetic and nongenetic variables that may affect clozapine plasma concentrations in Uruguayan patients with schizophrenia.
View Article and Find Full Text PDF[Clinical presentation and diagnosis of Parkinson's disease in patients with schizophrenia spectrum disorders].
Zh Nevrol Psikhiatr Im S S Korsakova
December 2024
Central State Medical Academy, Moscow, Russia.
Objective: To study the features of the clinical picture and diagnosis of Parkinson's disease (PD) in patients with schizophrenia spectrum disorders (SSD).
Material And Methods: The analysis of databases of four psychoneurological dispensaries in Moscow with the allocation of groups of patients with diagnoses of SSD (F20-F25 according to ICD-10) was carried out. Among these groups, a targeted search for patients with an established diagnosis of PD (G20) was conducted.
Lessons learnt in the end-of-life management of a hospice inpatient with advanced oropharyngeal cancer established on clozapine for treatment-resistant schizophrenia.
BMJ Case Rep
December 2024
Palliative Medicine, Aneurin Bevan University Health Board, Newport, UK.
Article Synopsis
- Clozapine is a critical medication for treatment-resistant schizophrenia but must be used carefully due to its narrow therapeutic range and potential for serious side effects.
- Patients with mental health issues often have heightened risks for head and neck cancers from lifestyle factors and may struggle to access adequate healthcare.
- Effective management requires careful planning, ongoing monitoring, and collaboration among healthcare professionals to balance the risks of clozapine toxicity and underdosing in patients with declining health.
Clozapine Toxicity Predictor: Deep neural network model predicting clozapine toxicity and its therapeutic dose range.
Psychiatry Res
December 2024
Medical University of Lodz, Department of Old Age Psychiatry and Psychotic Disorders, Czechosłowacka 8/10, 92-216 Łódź, Poland.
Article Synopsis
- * The study introduces a new deep neural network that predicts clozapine and norclozapine concentrations, toxicity, and therapeutic dose ranges using data from patients treated with clozapine.
- * This predictive model is freely available as a web application for clinicians, allowing improved management of clozapine dosing despite limited access to traditional therapeutic drug monitoring.
Clozapine for persons with neurodevelopmental disorders: a systematic review and expert recommendations for clinical practice.
Expert Rev Clin Pharmacol
October 2024
Psychiatry and Neurosciences Research Group (CTS-549), Mental Health Research Center at Eastern State Hospital, Lexington, KY, USA.
Introduction: We aimed to synthesize the information on the risks and benefits of clozapine prescription for resistant challenging behavior in persons with neurodevelopmental disorders.
Methods: Articles were identified with MEDLINE, Web of Sciences, and PsycINFO search from inception through January 2024. The review was restricted to persons with intellectual disability (ID) and/or autism spectrum disorder (ASD) without comorbid psychotic or affective disorder.
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