AI Article Synopsis
- - Disruptions in how membranes transport materials are linked to neurodevelopmental disorders, but the reasons behind this aren't fully understood.
- - O'Brien et al. (2023) investigate the role of a protein called GARP in regulating the transfer of sterols, which are important for dendrite remodeling in fruit flies.
- - Their findings provide insight into the mechanisms of membrane trafficking and its potential impact on understanding neurodevelopmental disorders.
Article Abstract
Disruptions in membrane trafficking are associated with neurodevelopmental disorders, but underlying pathological mechanisms remain largely unknown. In this issue, O'Brien et al. (2023. J. Cell Biol.https://doi.org/10.1083/jcb.202112108) show how GARP regulates sterol transfer critical for remodeling of dendrites in flies.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789741 | PMC |
| http://dx.doi.org/10.1083/jcb.202211072 | DOI Listing |
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