AI Article Synopsis
- Neuronal subtypes in the mammalian cortex are influenced by both internal and external factors during development, but there is a lack of understanding about the specific external cues involved.
- Researchers studied the role of sonic hedgehog (Shh) in determining glutamatergic neuron types in the cortex, finding that neurons born at E14.5 with high Shh levels often became layer 4 subtypes, unlike those born at E15.5.
- The study revealed that Shh influences neuron placement rather than directly activating the differentiation process for layer 4 neurons, highlighting its importance as an external factor in cortical layer specification.
Article Abstract
Neuronal subtypes in the mammalian cerebral cortex are determined by both intrinsic and extrinsic mechanisms during development. However, the extrinsic cues that are involved in this process remain largely unknown. Here, we investigated the role of sonic hedgehog (Shh) in glutamatergic cortical subtype specification. We found that E14.5-born, but not E15.5-born, neurons with elevated Shh expression frequently differentiated into layer 4 subtypes as judged by the cell positioning and molecular identity. We further found that this effect was achieved indirectly through the regulation of cell positioning rather than the direct activation of layer 4 differentiation programs. Together, we provided evidence that Shh, an extrinsic factor, plays an important role in the specification of cortical superficial layer subtypes.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787542 | PMC |
| http://dx.doi.org/10.3390/jdb10040050 | DOI Listing |
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