Background: The spontaneous regression of osteochondromas is rare, and only a few cases have been reported. Furthermore, the precise mechanism underlying spontaneous regression is unknown. This study aimed to examine the radiological findings of osteochondromas that had spontaneous regression and to identify potential indicators of this uncommon phenomenon in skeletally immature patients with osteochondromas.
Methods: We included 28 patients (15 males and 13 females) who met the eligibility criteria between 2002 and 2019. The mean age at initial diagnosis was 9.7 years old (2-16 years). The mean follow-up period was 6.4 years (3-16 years).
Results: Of the 28 patients, 10 (35.7%) had osteochondroma resolution. The osteochondroma resolved in one patient and regressed in nine. Tumor shrinkage is related to the thickness of the cartilage cap. The thickness of the cartilage cap did not correlate with age.
Conclusions: Tumor shrinkage is associated with a thinner cartilage cap on magnetic resonance imaging. The thickness of the cartilage cap may be an important predictor of spontaneous regression in pediatric patients with osteochondroma.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777135 | PMC |
| http://dx.doi.org/10.3390/curroncol29120777 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Incorporation of metal-doped silicate microparticles into collagen scaffolds combines chemical and architectural cues for endochondral bone healing.
Acta Biomater
December 2024
Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, BIH Center for Regenerative Therapies (BCRT), Charitéplatz 1, 10117 Berlin, Germany; Julius Wolff Institute, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, Berlin 13353, Germany; Berlin-Brandenburg School for Regenerative Therapies at Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, Berlin 13353, Germany. Electronic address:
Regeneration of large bone defects remains a clinical challenge until today. While existing biomaterials are predominantly addressing bone healing via direct, intramembranous ossification (IO), bone tissue formation via a cartilage phase, so-called endochondral ossification (EO) has been shown to be a promising alternative strategy. However, pure biomaterial approaches for EO induction are sparse and the knowledge how material components can have bioactive contribution to the required cartilage formation is limited.
View Article and Find Full Text PDFCartilage Endplate-Targeted Engineered Exosome Releasing and Acid Neutralizing Hydrogel Reverses Intervertebral Disc Degeneration.
Adv Healthc Mater
November 2024
Department of Orthopedics, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, 100000, China.
Article Synopsis
- - Cartilage endplate cell (CEPC) and nucleus pulposus cell (NPC) inflammation play a crucial role in intervertebral disc degeneration (IVDD), with iron ions and reactive oxygen species (ROS) being significant contributors to this process.
- - A new composite gel, CAP-sEXOs@Gel, has been developed, which uses engineered exosomes loaded with salvianolic acid A to target CEPCs and release them slowly, while also neutralizing the acidic environment to alleviate NPC inflammation.
- - The CAP-sEXOs@Gel effectively reduces intracellular iron and ROS levels, helping maintain mitochondrial function in CEPCs and suppressing inflammatory pathways, indicating its potential as a therapeutic strategy for reversing IVDD.
Endochondral ossification: Insights into the cartilage mineralization processes achieved by an anhydrous freeze substitution protocol.
Acta Biomater
January 2025
Centre for Ultrastructural Imaging (CUI), Kings College London, New Hunts House, Guys Hospital Campus, London SE1 1UL, UK. Electronic address:
Growth plate cartilage (GP) serves as a dynamic site of active mineralization and offers a unique opportunity to investigate the cell-regulated matrix mineralization process. Transmission electron microscopy (TEM) provides a means for the direct observation of these mechanisms, offering the necessary resolution and chemical analysis capabilities. However, as mineral crystallinity is prone to artifacts using aqueous fixation protocols, sample preparation techniques are critical to preserve the mineralized tissue in its native form.
View Article and Find Full Text PDFSelf-Healing Hyaluronic Acid-based Hydrogel with miRNA140-5p Loaded MON-PEI Nanoparticles for Chondrocyte Regeneration: Schiff Base Self-Assembly Approach.
Adv Sci (Weinh)
November 2024
Department of Orthopedics, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China.
Articular cartilage defects present a significant therapeutic challenge due to the inherent avascular and aneural characteristics of cartilage tissue. Gene therapy has emerged as a promising strategy for cartilage regeneration, particularly through the use of functional RNA and biomaterial-assisted frameworks. In this study, an innovative gene-activated self-healing hydrogel is developed and fabricated for the controlled release of miR140-5p, a key regulator of cartilage regeneration.
View Article and Find Full Text PDFIntra-Articular Osteochondroma in the Elbow: Diagnosis and Surgical Treatment in an 8-Year-Old Boy.
Am J Case Rep
October 2024
College of Medicine, King Khalid University, Abha, Saudi Arabia.
Article Synopsis
- Osteochondroma is the most prevalent benign bone tumor that can cause pain and restricted movement, especially in children, and this report examines a specific case involving an 8-year-old boy with an intra-articular osteochondroma in his elbow.
- The boy experienced persistent pain and limited motion in his elbow, leading to surgical intervention where a mass was successfully excised, and pathology confirmed the diagnosis.
- The report emphasizes the necessity of surgical removal and histopathological examination to correctly diagnose osteochondroma and differentiate it from other potential intra-articular conditions.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!