AI Article Synopsis
- * A study conducted on C57BL/6 mice showed that daily oral administration of AAE for 21 days led to improved hair characteristics, such as length, thickness, weight, and density.
- * The treatment increased gene expression of two important hair growth factors while suppressing 5α-reductase, suggesting that AAE may serve as a natural therapy for hair loss by enhancing the factors associated with hair growth.
Article Abstract
Hair loss is an important problem affecting the quality of life in modern society. Recent studies show that Annurca apple extract (AAE), enriched in procyanidin B2 and nutraceuticals, promotes hair growth and induces keratin production. In this study, we investigated the effects of AAE by orally administering AAE in six-week-old C57BL/6 mice once a day for 21 d. We observed improvement in hair length, thickness, weight, and density. The gene expression of two growth factors related to hair growth, vascular endothelial growth factor A () and fibroblast growth factor 7 (), were measured using the quantitative reverse transcription polymerase chain reaction (qRT-PCR). The gene expression of both and increased significantly in the AAE-treated group. Additionally, treatment with AAE suppressed the gene expression of type 1 5α-reductase. Histological analysis showed that protein levels of cytokeratin 5 and 10 were increased in the skin tissues of the AAE-treated group. These results suggest that AAE might be a potential therapeutic natural product that prevents hair loss by promoting the expression of hair growth-related factors.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776982 | PMC |
| http://dx.doi.org/10.3390/cimb44120428 | DOI Listing |
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