AI Article Synopsis
- PTSD and TBI are linked to a higher risk of developing Alzheimer's disease and related dementias (ADRD) in veterans.
- The study analyzed data from veterans of both European and African ancestry to evaluate how the presence of the APOE ε4 gene affects ADRD prevalence in those with PTSD and TBI.
- Results indicated that the risk of ADRD increased with more APOE ε4 alleles in individuals with PTSD and TBI, highlighting the importance of these factors in genetic testing and risk assessment for ADRD.
Article Abstract
Introduction: Post-traumatic stress disorder (PTSD) and traumatic brain injury (TBI) confer risk for Alzheimer's disease and related dementias (ADRD).
Methods: This study from the Million Veteran Program (MVP) evaluated the impact of apolipoprotein E (APOE) ε4, PTSD, and TBI on ADRD prevalence in veteran cohorts of European ancestry (EA; n = 11,112 ADRD cases, 170,361 controls) and African ancestry (AA; n = 1443 ADRD cases, 16,191 controls). Additive-scale interactions were estimated using the relative excess risk due to interaction (RERI) statistic.
Results: PTSD, TBI, and APOE ε4 showed strong main-effect associations with ADRD. RERI analysis revealed significant additive APOE ε4 interactions with PTSD and TBI in the EA cohort and TBI in the AA cohort. These additive interactions indicate that ADRD prevalence associated with PTSD and TBI increased with the number of inherited APOE ε4 alleles.
Discussion: PTSD and TBI history will be an important part of interpreting the results of ADRD genetic testing and doing accurate ADRD risk assessment.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10271966 | PMC |
| http://dx.doi.org/10.1002/alz.12870 | DOI Listing |
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