Colistin is a narrow-spectrum lipopeptide antimicrobial agent used to treat nosocomial infections caused by multidrug-resistant bacteria, especially in critically ill patients and those with cystic fibrosis. Colistin represents a concentration-time-dependent antibiotic with highly variable pharmacokinetics related to the heterogeneity of the target population and the necessity of bioactivation. Colistin is administered as the inactive prodrug colistimethate sodium. Nephrotoxicity and neurotoxicity are the most frequent adverse effects.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
[pharmacological properties
4
properties colistin]
4
colistin] colistin
4
colistin narrow-spectrum
4
narrow-spectrum lipopeptide
4
lipopeptide antimicrobial
4
antimicrobial agent
4
agent treat
4
treat nosocomial
4
nosocomial infections
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!