One of the Holocene abrupt events around 4200 years ago, lasting for ∼ 200 years, is thought to have caused cultural disruptions, yet terrestrial climatic status right after the cold/dry event remains poorly defined and is often presumed that a generally cool condition prevailed during the Bronze Age (∼ 4000-2200 years ago). Here we report an alkenone-based summer temperature record over the past ∼ 12,000 years, in addition to two updated alkenone records, from Northwest China, providing new insights into the climatic status right after the event. Our results indicate that exceptional terrestrial warmth, up to ∼ 6 °C, occurred around 4200-2800 years ago during the Bronze Age, superimposed on the long-term Holocene cooling trend. The exceptional warmth in Northwest China, together with other climate anomalies elsewhere, suggests an unusual large-scale climatic reorganization at 4200-2800 years ago when solar activity remained high, with important implications to the climate background for cultural developments during the Bronze Age.
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http://dx.doi.org/10.1016/j.scib.2021.11.001 | DOI Listing |
Alzheimers Dement
December 2024
Dementia and Neurodegenerative Disease Research Center, Inje University, St Charles, Korea, Republic of (South); Department of Neurology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea, Republic of (South); Inje University College of Medicine, BUSAN, Korea, Republic of (South).
Background: Because of clinically overlapping parkinsonian motor symptoms, it is hard to diagnose a specific disease in atypical parkinsonism or differentiate Parkinson's disease (PD) from atypical parkinsonism. Herein, we report the clinicopathological mismatching of an autopsy-confirmed PSP in a patient clinically diagnosed with PD.
Method Clinical History: We reviewed the brief clinical history of a 70-year-old man and neurologic examination.
Alzheimers Dement
December 2024
Seoul National University, School of Medicine, Seoul, Korea, Republic of (South).
Background: We herein introduce a case that was pathologically confirmed as an advanced stage of LATE.
Method: (case presentation) An 81-year-old woman visited a memory clinic complaining of memory impairment in the past few years. She had no psychiatric history and a history of significant hyperlipidemia and hypertension.
Mol Biol Evol
January 2025
Swiss Institute of Bioinformatics, Basel, Switzerland.
Bacterial genomes primarily diversify via gain, loss, and rearrangement of genetic material in their flexible accessory genome. Yet the dynamics of accessory genome evolution are very poorly understood, in contrast to the core genome where diversification is readily described by mutations and homologous recombination. Here, we tackle this problem for the case of very closely related genomes.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Koc University, Department Biology and Genetics, Istanbul, Turkey.
Background: Valosin Containing Protein (VCP) mutations are responsible some genetic etiologies of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
Method: A 67-year-old, male patient, applied to the clinic due to behavioral changes and difficulty swallowing. According the patient history it was reported that his first complaint started 6 years ago (at the age of 61).
Alzheimers Dement
December 2024
Neurogenetics Working Group, Universidad Científica del Sur, Lima, Peru.
Amerindian (AI) populations are substantially underrepresented in AD genetic studies. The Alzheimer's Disease Sequencing Project (ADSP), a global genetic initiative established by the National Institute of Aging (NIA) is supporting regional initiatives in Latin America and its admixed population. Latin America is the largest recently admixed population, with variable Native American, European, and African ancestry proportions, as result of successive settlements and new massive migrations.
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