Risk mitigation is usually addressed in simulated environments for safety critical control. The migration of the final controller requires further adjustments due to the simulation assumptions and constraints. This paper presents the design of an experience inference algorithm for safety critical control of unknown multi-agent linear systems. The approach is inspired in the close relationship between three main areas of the brain cortex that enables transfer learning and decision making: the hippocampus, the neocortex, and the striatum. The hippocampus is modelled as a stable linear model that communicates to the striatum how the real-world system is expected to behave. The hippocampus model is controlled by an adaptive dynamic programming (ADP) algorithm to achieve an optimal desired performance. The neocortex and the striatum are designed simultaneously by an actor control policy algorithm that ensures experience inference to the real-world system. Experimental and simulations studies are carried out to verify the proposed approach.
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http://dx.doi.org/10.1016/j.isatra.2022.12.011 | DOI Listing |
BMC Bioinformatics
January 2025
Biology Department, University of Massachusetts Amherst, Amherst, MA, USA.
Background: High-throughput behavioral analysis is important for drug discovery, toxicological studies, and the modeling of neurological disorders such as autism and epilepsy. Zebrafish embryos and larvae are ideal for such applications because they are spawned in large clutches, develop rapidly, feature a relatively simple nervous system, and have orthologs to many human disease genes. However, existing software for video-based behavioral analysis can be incompatible with recordings that contain dynamic backgrounds or foreign objects, lack support for multiwell formats, require expensive hardware, and/or demand considerable programming expertise.
View Article and Find Full Text PDFUnlabelled: Autism Spectrum Disorder (ASD) is characterized by restricted and repetitive behaviors and social differences, both of which may manifest, in part, from underlying differences in corticostriatal circuits and reinforcement learning. Here, we investigated reinforcement learning in mice with mutations in either or , both high-confidence ASD risk genes associated with major syndromic forms of ASD. Using an odor-based two-alternative forced choice (2AFC) task, we tested adolescent mice of both sexes and found male and heterozygote (Het) mice showed enhanced learning performance compared to their wild type (WT) siblings.
View Article and Find Full Text PDFJ Clin Nurs
January 2025
Institute of Health and Care Sciences, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Aim: To explore the meaning of adaptation after visceral transplantation in terms of patient experiences, symptoms, self-efficacy, transplant-specific and mental well-being.
Design: A convergent parallel mixed-methods study, consisting of interviews and generic as well as transplant-specific questionnaires. Results were integrated using meta-inference.
Sensors (Basel)
January 2025
School of Communication and Information Engineering, Xi'an University of Science and Technology, Xi'an 710054, China.
Artificial intelligence (AI), particularly through advanced large language model (LLM) technologies, is reshaping coal mine safety assessment methods with its powerful cognitive capabilities. Given the dynamic, multi-source, and heterogeneous characteristics of data in typical mining scenarios, traditional manual assessment methods are limited in their information processing capacity and cost-effectiveness. This study addresses these challenges by proposing an embodied intelligent system for mine safety assessment based on multi-level large language models (LLMs) for multi-source sensor data.
View Article and Find Full Text PDFStat Med
February 2025
Department of Statistics, University of California, Davis, California, USA.
A causal mediation model with multiple time-to-event mediators is exemplified by the natural course of human disease marked by sequential milestones with a time-to-event nature. For example, from hepatitis B infection to death, patients may experience intermediate events such as liver cirrhosis and liver cancer. The sequential events of hepatitis, cirrhosis, cancer, and death are susceptible to right censoring; moreover, the latter events may preclude the former events.
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