AI Article Synopsis
- Pneumolysin is a harmful substance made by a bacteria called Streptococcus pneumoniae that affects how the bacteria interacts with the body during serious infections like meningitis.
- Researchers studied how pneumolysin affects both the bacteria and zebrafish, helping to understand how it makes the infection worse and how the body tries to fight back.
- They found that a process called necroptosis, which helps the body survive, is really important, and using a certain drug made it harder for the body to fight the infection, leading to more deaths.
Article Abstract
Pneumolysin is a major virulence factor of Streptococcus pneumoniae that plays a key role in interaction with the host during invasive disease. How pneumolysin influences these dynamics between host and pathogen interaction during early phase of central nervous system infection in pneumococcal meningitis remains unclear. Using a whole-animal in vivo dual RNA sequencing (RNA-seq) approach, we identify pneumolysin-specific transcriptional responses in both S. pneumoniae and zebrafish (Danio rerio) during early pneumococcal meningitis. By functional enrichment analysis, we identify host pathways known to be activated by pneumolysin and discover the importance of necroptosis for host survival. Inhibition of this pathway using the drug GSK'872 increases host mortality during pneumococcal meningitis. On the pathogen's side, we show that pneumolysin-dependent competence activation is crucial for intra-host replication and virulence. Altogether, this study provides new insights into pneumolysin-specific transcriptional responses and identifies key pathways involved in pneumococcal meningitis.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794515 | PMC |
| http://dx.doi.org/10.1016/j.celrep.2022.111851 | DOI Listing |
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