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Wildfire-related PM and DNA methylation: An Australian twin and family study. | LitMetric

Wildfire-related PM and DNA methylation: An Australian twin and family study.

Environ Int

School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3004, Australia. Electronic address:

Published: January 2023

AI Article Synopsis

  • The study investigates how long-term exposure to fine particulate matter (PM) from wildfires affects DNA methylation in humans, focusing on 479 Australian women, including twin pairs and their sisters.
  • Researchers measured blood DNA methylation and correlated it with exposure to wildfire-related PM versus non-wildfire-related PM using advanced data collection methods.
  • Results indicated a negative, but not significant, association between wildfire PM and global DNA methylation, finding specific CpGs and differential methylated regions linked to genes involved in inflammatory responses and various diseases like cancer and diabetes.

Article Abstract

Background: Wildfire-related fine particulate matter (PM) has many adverse health impacts, but its impacts on human epigenome are unknown. We aimed to evaluate the associations between long-term exposure to wildfire-related PM and blood DNA methylation, and whether the associations differ from those with non-wildfire-related PM.

Methods: We studied 479 Australian women comprising 132 twin pairs and 215 of their sisters. Blood-derived DNA methylation was measured using the HumanMethylation450 BeadChip array. Data on 3-year (year of blood collection and previous two years) average wildfire-related and non-wildfire-related PM at 0.01°×0.01° spatial resolution were created by combining information from satellite observations, chemical transport models, and ground-based observations. Exposure data were linked to each participant's home address, assuming the address did not change during the exposure window. For DNA methylation of each cytosine-guanine dinucleotide (CpG), and for global DNA methylation represented by the average of all measured CpGs or CpGs in repetitive elements, we evaluated their associations with wildfire- or non-wildfire-related PM using a within-sibship analysis controlling for factors shared between siblings and other important covariates. Differentially methylated regions (DMRs) were defined by comb-p and DMRcate.

Results: The 3-year average wildfire-related PM (range: 0.3 to 7.6 µg/m mean: 1.6 µg/m) was negatively, but not significantly (p-values greater than 0.05) associated with all seven global DNA methylation measures. There were 26 CpGs and 33 DMRs associated with wildfire-related PM (Bonferroni adjusted p-value < 0.05) mapped to 47 genes enriched for pathways related to inflammatory regulation and platelet activation. These genes have been related to many human diseases or phenotypes e.g., cancer, mental disorders, diabetes, obesity, asthma, blood pressure. These CpGs, DMRs and enriched pathways did not overlap with the 1 CpG and 7 DMRs associated with non-wildfire-related PM.

Conclusions: Long-term exposure to wildfire-related PM was associated with various blood DNA methylation signatures in Australian women, and these were distinct from those associated with non-wildfire-related PM.

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Source
http://dx.doi.org/10.1016/j.envint.2022.107704DOI Listing

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