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Koala populations show marked differences in inbreeding levels and in the presence or absence of the endogenous Koala retrovirus (KoRV). These genetic differences among populations may lead to severe disease impacts threatening koala population viability. In addition, the recent colonization of the koala genome by KoRV provides a unique opportunity to study the process of retroviral adaptation to vertebrate genomes and the impact this has on speciation, genome structure, and function. The genome build described here is from an animal from the bottlenecked Southern population free of endogenous and exogenous KoRV. It provides a more contiguous genome build than the previous koala reference derived from an animal from a more outbred Northern population and is the first koala genome from a KoRV polymerase-free animal.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887267 | PMC |
http://dx.doi.org/10.1093/gbe/evac176 | DOI Listing |
BMC Public Health
December 2024
Department of English Language, Kotebe Metropoliatan University, Addis Ababa, Ethiopia.
Background: Community acceptance of Traditional birth attendants (TBAs) as professional birth attendant was reported as one of the bottlenecks that has been hindering facility childbirth care service use. Hence, the World Health Organization (WHO) recommended that all childbirths needed to be attended by professional skilled attendants who at least possessed midwifery skill through the safe motherhood initiative. However, many births in developing countries have been being attended by Traditional birth attendants (TBAs) mainly due to pregnant women and community acceptance for TBAs as sole birth attendants.
View Article and Find Full Text PDFSci Data
December 2024
Southern Methodist University Department of Chemistry, Dallas, TX, USA.
The growing popularity of machine learning (ML) and deep learning (DL) in scientific fields is hindered by the scarcity of high-quality datasets. While quantum mechanical (QM) predictions using DL techniques such as graph neural networks (GNNs) and generative models are gaining traction, insufficient training data remains a bottleneck. The QM40 dataset addresses this challenge by representing 88% of the FDA-approved drug chemical space.
View Article and Find Full Text PDFJ Am Chem Soc
December 2024
Department of Materials Science and Engineering, and Shenzhen Engineering Research and Development Center for Flexible Solar Cells, Southern University of Science and Technology, Shenzhen 518055, China.
Chemically modifiable small-molecule hole transport materials (HTMs) hold promise for achieving efficient and scalable perovskite solar cells (PSCs). Compared to emerging self-assembled monolayers, small-molecule HTMs are more reliable in terms of large-area deposition and long-term operational stability. However, current small-molecule HTMs in inverted PSCs lack efficient molecular designs that balance both the charge transport capability and interface compatibility, resulting in a long-standing stagnation of power conversion efficiency (PCE) below 24.
View Article and Find Full Text PDFZoo Biol
December 2024
Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan.
Molecular genetic analyses are effective in revealing the origin, kinship, and genetic diversity of zoo animals. In this study, we carried out the genetic characterization of captive founder individuals of the South American fur seal (Arctocephalus australis) in Japanese zoos and aquariums based on analyses of mitochondrial sequences and nuclear microsatellite loci. In mitochondrial DNA analysis, the haplotype diversity and nucleotide diversity of the overall population were 0.
View Article and Find Full Text PDFActa Biomater
December 2024
Department of Internal Medicine, Section of Cardiovascular Medicine, Yale Cardiovascular Research Center, Yale School of Medicine, 300 George Street, New Haven, CT 06511, USA; Yale Stem Cell Center, 10 Amistad Street, New Haven, CT 06511, USA; Department of Pathology, Yale University, New Haven, CT 06510, USA; Department of Biomedical Engineering, Yale University, New Haven, CT 06519, USA. Electronic address:
Induced pluripotent stem cells (iPSCs) hold great promise for the treatment of cardiovascular diseases through cell-based therapies, but these therapies require extensive preclinical testing that is best done in species-in-species experiments. Pigs are a good large animal model for these tests due to the similarity of their cardiovascular system to humans. However, a lack of adequate pig iPSCs (piPSCs) that are analogous to human iPSCs has greatly limited the potential usefulness of this model system.
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