AI Article Synopsis
- The study found that exposure to pyriproxyfen (PPF) in zebrafish led to higher levels of reactive oxygen species and lower glutathione, indicating oxidative stress in the ovaries.
- It showed increased activity of certain antioxidant enzymes but unchanged activity of γ-glutamyltransferase, suggesting the fish's response to oxidative damage.
- Histological analysis revealed changes in ovarian structure, including fewer mature oocytes and increased atresia, highlighting PPF's role as an endocrine disruptor that may negatively impact fish reproduction.
Article Abstract
We analyzed the effects of pyriproxyfen (PPF) on oxidative stress and ovarian morphology in zebrafish. PPF (10 M) exposure increased reactive oxygen species generation in ovaries, in association with a decrease in glutathione content. The activities of glutathione S-transferase, superoxide dismutase, and catalase were increased, while γ-glutamyltransferase activity was not altered by pesticide treatment. The histology of ovarian tissue showed an increase in the number of previtellogenic oocytes I, and a decrease in the rate of vitellogenic oocyte (VIT) count, suggesting inhibition of follicular maturation. An increase in the thickness of the vitelline envelope was observed in VIT, as was a tendency toward an increase in atresia in the ovary of the PPF-treated group. These findings indicate that the deleterious effect of PPF on ovarian maturation is mediated by a redox imbalance and oxidative damage. So, PPF acts as an endocrine disruptor chemical and may compromise fish reproduction by reducing female fertility.
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| http://dx.doi.org/10.1002/jat.4425 | DOI Listing |
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