Liquid-liquid phase separation drives herpesvirus assembly in the cytoplasm.

J Cell Biol

Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea.

Published: January 2023

Liquid-liquid phase separation (LLPS) has emerged as a fundamental mechanism to compartmentalize biomolecules into membraneless organelles. In this issue, Zhou et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202201088), report that MHV-68 ORF52 undergoes LLPS to form cytoplasmic virion assembly compartments, regulating the spatiotemporal compartmentalization of viral components.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779906PMC
http://dx.doi.org/10.1083/jcb.202211015DOI Listing

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