Purpose Of Review: Numerous innovations have been made since the first inflatable penile prosthesis was introduced in 1973-not just of the implant apparatus itself, but crucially also in the surgical instruments used for prosthetic surgery. Starting with Dr. Furlow's revolutionary inserter tool, advancements were quickly made in dilators, retractors, and cavernotomes.
Recent Findings: More recent innovations have been made in inserter tools, forceps, needle holders, clamps, and disposable instruments. Leading companies Boston Scientific and Coloplast have contributed significantly to the evolution of IPP surgical placement, and companies such as Uramix and Rigicon are developing a wide array of new specialized tools. We aim to summarize the instruments needed for IPP placement, with a focus on describing the variety of instrument innovations since Dr. Brantley Scott designed and placed the first IPP.
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http://dx.doi.org/10.1007/s11934-022-01136-3 | DOI Listing |
Bio Protoc
December 2024
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China.
MicroRNAs (miRNAs) are small, non-coding RNAs that play pivotal roles in gene regulation; they are increasingly recognized as vital biomarkers for various diseases, notably cancer. Conventional methods for miRNA detection, such as quantitative PCR and microarray analysis, often entail intricate sample preparation and lack the requisite sensitivity to detect low-abundance miRNAs like miRNA-21. This protocol presents an innovative approach that combines branched hybridization chain reaction (bHCR) with DNAzyme technology for the precise detection of miRNA-21.
View Article and Find Full Text PDFFront Robot AI
December 2024
CREATE-Lab, Department of Mechanical Engineering, Swiss Federal Technology Institute of Lausanne (EPFL), Lausanne, Switzerland.
Creativity and style in music playing originates from constraints and imperfect interactions between instruments and players. Digital and robotic systems have so far been unable to capture this naturalistic playing. Whether as an additional tool for musicians, function restoration with prosthetics, or artificial intelligence-powered systems, the physical embodiment and interactions generated are critical for expression and connection with an audience.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
December 2024
Centre for Nutrition and Food Sciences (CNAFS), Queensland Alliance for Agriculture and Food Innovation (QAAFI), Brisbane, Queensland 4072, Australia. Electronic address:
The black soldier fly larvae (BSFL) are well known to utilise a wide variety of organic waste streams, delivering a product rich in protein (30-50%) and lipids (15-49%) and other micronutrients. The objective of this study was to evaluate the ability of NIR spectroscopy combined with chemometrics to predict the concentration of fatty acids in BSFL reared in different commercial waste streams. Intact BSFL samples were analysed using a bench top NIR instrument where calibration models for fatty acids were developed using partial least squares (PLS) regression.
View Article and Find Full Text PDFKorean Circ J
November 2024
Department of Structural Heart Disease, National Center for Cardiovascular Disease & Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.
Background And Objectives: There is no dedicated occlusive device for closing coronary artery fistulas (CAFs), and specific efficacy and safety data of various off-label occlusive devices for CAFs closure are scarce.
Methods: Patients undergoing transcatheter closure of CAFs from January 2011 to December 2022 were included in the single-center retrospective study. The study population was divided into 2 groups: coils group (n=35) and patent ductus arteriosus (PDA) occluders group (n=66).
Sci Rep
December 2024
Department of Biochemistry, Faculty of Science, Mahidol University, 272 Rama VI Road, Thung Phayathai, Ratchathewi, Bangkok, 10400, Thailand.
Wnt signaling is a critical pathway implicated in cancer development, with Frizzled proteins, particularly FZD10, playing key roles in tumorigenesis and recurrence. This study focuses on the potential of repurposed FDA-approved drugs targeting FZD10 as a therapeutic strategy for nasopharyngeal carcinoma (NPC). The tertiary structure of human FZD10 was constructed using homology modeling, validated by Ramachandran plot and ProQ analysis.
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