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Molecular Design of Encapsulin Protein Nanoparticles to Display Rotavirus Antigens for Enhancing Immunogenicity.
Vaccines (Basel)
September 2024
InThera, Inc., Seoul 05836, Republic of Korea.
Rotavirus considerably threatens global health, particularly for children <5 years. Current, licensed oral attenuated vaccine formulations have limitations including insufficient efficacy in children in low- and middle-income countries, warranting urgent development of novel vaccines with improved efficacy and safety profiles. Herein, we present a novel approach utilizing an encapsulin (ENC) nanoparticle (NP)-based non-replicating rotavirus vaccine.
View Article and Find Full Text PDFNonstructural protein 4 of human norovirus self-assembles into various membrane-bridging multimers.
J Biol Chem
September 2024
Université Paris-Saclay, CEA, CNRS - Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France. Electronic address:
Single-stranded, positive-sense RNA ((+)RNA) viruses replicate their genomes in virus-induced intracellular membrane compartments. (+)RNA viruses dedicate a significant part of their small genomes (a few thousands to a few tens of thousands of bases) to the generation of these compartments by encoding membrane-interacting proteins and/or protein domains. Noroviruses are a very diverse genus of (+)RNA viruses including human and animal pathogens.
View Article and Find Full Text PDFIs There a Functional Role for the Knotted Topology in Protein UCH-L1?
J Chem Inf Model
September 2024
BioISI - Instituto de Biossistemas e Ciências Integrativas, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa, Portugal.
Knotted proteins are present in nature, but there is still an open issue regarding the existence of a universal role for these remarkable structures. To address this question, we used classical molecular dynamics (MD) simulations combined with experiments to investigate the role of the Gordian knot in the catalytic activity of UCH-L1. To create an unknotted form of UCH-L1, we modified its amino acid sequence by truncating several residues from its N-terminus.
View Article and Find Full Text PDFLong term rescue of Alzheimer's deficits by one-time gene-editing of C-terminus.
bioRxiv
June 2024
Department of Pathology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, USA.
Gene-editing technologies promise to create a new class of therapeutics that can achieve permanent correction with a single intervention. Besides eliminating mutant alleles in familial disease, gene-editing can also be used to favorably manipulate upstream pathophysiologic events and alter disease-course in wider patient populations, but few such feasible therapeutic avenues have been reported. Here we use CRISPR-Cas9 to edit the last exon of amyloid precursor protein (), relevant for Alzheimer's disease (AD).
View Article and Find Full Text PDFAuthor Correction: Precision nutrition to reset virus-induced human metabolic reprogramming and dysregulation (HMRD) in long-COVID.
NPJ Sci Food
May 2024
Global Nutrition Healthcare Council (GNHC) Mission-COVID, Yorba Linda, CA, USA.
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