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Exploring the key pathogenic mechanisms and potential intervention targets for in managing bone metastasis of lung cancer based on network pharmacology and molecular docking techniques.
Transl Cancer Res
October 2024
Department of Ultrasound, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China.
Article Synopsis
- The study focuses on discovering new treatments for lung cancer that has spread to bones, emphasizing the importance of using traditional Chinese medicine (TCM).
- Active compounds from TCM were identified, leading to the detection of 227 target genes and 952 differentially expressed genes related to bone metastasis in lung cancer.
- The research identified a specific gene that correlates with patient survival, highlighting potential therapeutic targets and mechanisms for tackling lung cancer bone metastasis.
In Silico Analysis Uncovers FOXA1 as a Potential Biomarker for Predicting Neoadjuvant Chemotherapy Response in Fine-Needle Aspiration Biopsies.
J Cancer
September 2024
Department of General surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
The preoperative identification of neoadjuvant chemotherapy (NAC) treatment responsiveness in breast cancer (BC) patients is advantageous for tailoring treatment regimens. There is a relative scarcity in the current research exploring NAC treatment responsive biomarkers using bulk sequencing data obtained from fine-needle aspiration (FNA). Limma was employed for the selection of differentially expressed genes.
View Article and Find Full Text PDFSingle-Cell Transcriptomics Reveals a Pivotal Role of DOCK2 in Sjögren Disease.
ACR Open Rheumatol
December 2024
Article Synopsis
- Sjögren disease (SjD) is an autoimmune disorder affecting salivary and tear glands; the study focused on understanding the immune cell types and their pathways involved in this condition.
- Researchers used single-cell RNA sequencing to analyze immune cell compositions in SjD mouse models, identifying key cell populations and their specific genes associated with the disease.
- Treatment with a DOCK2 inhibitor showed promising results in reducing SjD symptoms, suggesting that targeting DOCK2 could be a viable strategy for improving treatment outcomes in SjD patients.
Integrative ATAC-seq and RNA-seq analysis associated with diabetic nephropathy and identification of novel targets for treatment by dapagliflozin.
Cell Biochem Funct
March 2024
Department of Nephrology, Molecular Cell Lab for Kidney Disease, Shanghai Peritoneal Dialysis Research Center, Ren Ji Hospital, Uremia Diagnosis and Treatment Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Dapagliflozin (DAPA) are clinically effective in improving diabetic nephropathy (DN). However, whether and how chromatin accessibility changed by DN responds to DAPA treatment is unclear. Therefore, we performed ATAC-seq, RNA-seq, and weighted gene correlation network analysis to identify the chromatin accessibility, the messenger RNA (mRNA) expression, and the correlation between clinical phenotypes and mRNA expression using kidney from three mouse groups: db/m mice (Controls), db/db mice (case group), and those treated with DAPA (treatment group).
View Article and Find Full Text PDFThe Rac-GEF Tiam1 controls integrin-dependent neutrophil responses.
Front Immunol
December 2023
Signalling Programme, Babraham Institute, Cambridge, United Kingdom.
Rac GTPases are required for neutrophil adhesion and migration, and for the neutrophil effector responses that kill pathogens. These Rac-dependent functions are impaired when neutrophils lack the activators of Rac, Rac-GEFs from the Prex, Vav, and Dock families. In this study, we demonstrate that Tiam1 is also expressed in neutrophils, governing focal complexes, actin cytoskeletal dynamics, polarisation, and migration, in a manner depending on the integrin ligand to which the cells adhere.
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