The present study aims to evaluate the influence of different positioning of the hip femoral prosthesis on the stress and strain over this implant. A femoral prosthesis (Taper - Víncula, Rio Claro, SP, Brazil) was submitted to a stress and strain analysis using the finite element method (FEM) according to the standard. The analysis proposed a branch of the physical test with a +/- 5° angle variation on the standard proposed for α and β variables. The isolated +/- 5° variation on the α angle, as well as the association of +/- 5° variation on the α and β angles, presented significant statistical differences compared with the control strain ( = 0.027 and 0.021, respectively). Variation on angle β alone did not result in a significant change in the strain of the prosthesis ( = 0.128). The stem positioning with greatest implant strain was α = 5° and β = 14° ( = 0.032). A variation on the positioning of the prosthetic femoral stem by +/- 5° in the coronal plane and/or the association of a +/- 5° angle in coronal and sagittal planes significantly influenced implant strain.
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http://dx.doi.org/10.1055/s-0041-1735141 | DOI Listing |
J Orthop
June 2025
The Affiliated Hospital of Qingdao University, Qingdao Cancer Institute, Qingdao University, Qingdao, 266071, China.
Study Objective: This study aims to validate the application effects of a novel theoretical model of dynamic parallel traction in the treatment of femoral neck fractures through three-dimensional finite element analysis. By simulating the femoral neck fracture model, we explore the promotional effect of dynamic parallel traction on fracture healing.
Method: A digital 3D femur model was constructed using high-resolution computed tomography data of the lower limbs of a 70-year-old elderly subject.
ACS Bio Med Chem Au
October 2024
Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
Darunavir, a frontline treatment for HIV infection, faces limitations due to emerging multidrug resistant (MDR) HIV strains, necessitating the development of analogs with improved activity. In this study, a combinatorial in silico approach was used to initially design a series of HIV-1 PI analogs with modifications at key sites, P1' and P2', to enhance interactions with HIV-1 PR. Fifteen analogs with promising binding scores were selected for synthesis and evaluated for the HIV-1 PR inhibition activity.
View Article and Find Full Text PDFVirulence
December 2024
Shandong Academy of Agricultural Sciences, Institute of Poultry Science, Jinan, Shandong, China.
Recombinant Muscovy duck parvovirus (rMDPV) is a product of genetic recombination between classical Muscovy duck parvovirus (MDPV) and goose parvovirus (GPV). The recombination event took place within a 1.1-kb DNA segment located in the middle of the VP3 gene, and a 187-bp sequence extending from the P9 promoter to the 5' initiation region of the Rep1 ORF.
View Article and Find Full Text PDFFront Physiol
May 2024
Department of Poultry Science, College of Agricultural and Environmental Sciences, University of Georgia, Athens, GA, United States.
Background: Coccidiosis outbreaks in susceptible laying hens can significantly decrease egg production and cause substantial economic loss to the egg industry. The supplementation of poultry diets with chemotherapeutic agents is limited due to antimicrobial resistance and residue in poultry meat or processed products. Therefore, alternative strategies to control coccidiosis are needed, and () might have the potential to be a phytogenic feed additive, an alternative to anticoccidial agents.
View Article and Find Full Text PDFJ Agric Food Chem
June 2024
State & Local Joint Engineering Research Center of Green Pesticide Invention and Application, College of Plant Protection, Nanjing Agricultural University, Nanjing, Jiangsu 210095, People's Republic of China.
Plant pathogenic fungi pose a significant threat to agricultural production, necessitating the development of new and more effective fungicides. The ring replacement strategy has emerged as a highly successful approach in molecular design. In this study, we employed the ring replacement strategy to successfully design and synthesize 32 novel hydrazide derivatives containing diverse heterocycles, such as thiazole, isoxazole, pyrazole, thiadiazole, 1,3,4-oxadiazole, 1,2,4-oxadiazole, thiophene, pyridine, and pyrazine.
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