The present paper examined the contribution of optimism and humor styles to well-being during the COVID-19 lockdown period. Furthermore, we examined whether these direct associations were mediated by two common COVID-19 challenges--work-family interface (WFI) and COVID-19 fears. Israeli employees ( = 356) completed an online survey during lockdown restrictions (69% women, 57.20% held academic degrees, = 30.70, age-range = 20-61). Both optimism and adaptive humor revealed a positive and direct effect on well-being. Furthermore, mediation analyses indicated that both fear of COVID-19 and WFI mediated the direct associations between optimism and well-being, as well as the direct associations between maladaptive humor and well-being, whereas WFI mediated the association between adaptive humor and well-being. These findings stress the need to adapt interventions derived from positive psychology to enhance well-being during these challenging times of COVID-19.
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http://dx.doi.org/10.1016/j.paid.2021.111164 | DOI Listing |
Am Soc Clin Oncol Educ Book
January 2025
Department of Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
Cell-based therapies have become integral to the routine clinical management of hematologic malignancies. Tumor-infiltrating lymphocyte (TIL) therapy has demonstrated efficacy in immunogenic solid tumors, such as melanoma. However, in the GI field, evidence supporting the clinical success of cell-based therapies is still awaited.
View Article and Find Full Text PDFHealth Aff (Millwood)
January 2025
Anne Zink, Palmer, Alaska.
The United States faces urgent public health challenges, including high preventable death rates, pervasive health disparities, and emerging health risks, despite unprecedented medical progress. This article, part of the National Academy of Medicine's Vital Directions for Health and Health Care: Priorities for 2025 initiative, presents a vision for modernizing the US public health system to address these twenty-first-century challenges through federally supported partnerships with health care, social services, and community organizations. We identify actions to address persistent public health challenges that stem from insufficient and fragmented funding models, inadequate data infrastructure, workforce vulnerabilities, and limited public trust.
View Article and Find Full Text PDFHealth Aff (Millwood)
January 2025
Victor J. Dzau, National Academy of Medicine, Washington, D.C.
The US biomedical research enterprise is renowned for its historical and ongoing scientific breakthroughs and advancements. Yet its capacity to solve complex health issues, bridge health equity gaps, and strengthen public trust is constrained by the lack of an overarching national vision, fragmented coordination for research funding, and critical workforce recruitment and retention challenges. To improve national health outcomes and retain global competitiveness, the sector must embrace new approaches.
View Article and Find Full Text PDFPLoS One
January 2025
Pfizer Ltd., Tadworth, United Kingdom.
Background: Risk factors and comorbidities can complicate management of non-valvular atrial fibrillation. We describe and compare real-world safety and effectiveness of direct oral anticoagulants (DOACs; apixaban, rivaroxaban, dabigatran) and vitamin K antagonists (VKAs) in subgroups of patients with non-valvular atrial fibrillation at high risk for gastrointestinal (GI) bleeding, utilizing data from a national quasi-exhaustive French database.
Methods: Anticoagulant-naïve adults with non-valvular atrial fibrillation with ≥1 gastrointestinal bleeding risk factor, initiating anticoagulant treatment January 2016-December 2019, and covered by the French national health data system were eligible.
Nutr Rev
January 2025
College of Education, Psychology and Social Work, Flinders University, Bedford Park, SA 5001, Australia.
The purpose of the present narrative review was to propose a unifying generalized conceptual model of mechanisms and processes in appetite self-regulation (ASR) in childhood. Appetite self-regulation, along with other domains of self-regulation, develops across childhood and contributes to energy intake and balance, diet quality, weight, and therefore long-term health outcomes. There have been efforts to conceptualize and measure components of ASR and associated processes/mechanisms, but, at present, there is no unifying conceptualization of ASR in childhood.
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