Association between and additional chromosomal abnormalities in the prognosis of acute promyelocytic leukemia.

Objectives: Internal tandem duplications of the Fms-like tyrosine kinase 3 gene ( and additional chromosomal abnormalities (ACA) are prognostic factors in patients with acute promyelocytic leukemia (APL). This study aimed to determine the effect of the association between and ACA in the prognosis of APL.

Methods: This was a retrospective cohort study including 60 patients with APL treated with all-trans retinoic acid (ATRA) and chemotherapy. Five-year overall survival (OS) and progression-free survival (PFS) were analyzed in patient groups according to the presence of and ACA.

Results: was an independent adverse factor for 5-year PFS, and ACA was an independent adverse factor for 5-year OS. There were significant differences in OS and PFS among the groups: -negative without ACA, -positive without ACA, -negative with ACA, and -positive with ACA. The OS times were 52.917, 45.813, 25.375, and 23.417 months, and the PFS times were 48.833, 38.563, 23.250, and 17.333 months, respectively.

Conclusion: and ACA are associated with the poorest OS and PFS outcomes in patients with APL treated with chemotherapy plus ATRA.