AI Article Synopsis
- Drug-related problems (DRPs) are significant but preventable issues patients face due to medication use or misuse, yet current prevention policies are inadequate.
- A clinical trial conducted with 769 adult patients visiting the emergency department for DRPs evaluated the effectiveness of a specialized prevention bundle versus standard care, focusing on readmission rates within 30 days.
- Results indicated that the intervention group had a lower readmission rate (7.3%) compared to the control group (10.4%), suggesting that the DRP prevention bundle could effectively reduce hospital readmissions.
Article Abstract
Background: Drug-related problems (DRPs) are prevalent and avoidable disease that patients experience due to drug use or nonuse. However, secondary prevention policies have not yet been systematized.
Objective: To assess the clinical impact of a secondary prevention bundle for DRPs in patients who visited the emergency department (ED) for medicine-related problems.
Methods: A single-center randomized clinical trial was conducted from August 28, 2019, to January 28, 2021, with 1-month follow-up. We included 769 adult patients who visited ED with a DRP associated with cardiovascular, alimentary tract, and metabolic system medications. For the intervention group, a DRP prevention bundle, consisting of a combined strategy initiated in the ED was applied. Patients in the control group received standard pharmaceutical care. Intervention was evaluated in terms of 30-day hospital readmission due to any cause.
Results: Final analysis included 769 patients, of which 68 (8.8%) were readmitted within 30 days (control group, 40 of 386 [cumulative incidence: 10.4%]; intervention group, 28 of 383 [cumulative incidence, 7.3%]). After adjustment of the model for chronic heart failure, there was a lower incidence of hospital readmission among patients in the intervention group compared with those in the control group, odds ratio: 0.59 [95% confidence interval: 0.37-0.97]; number needed to treat (NNT) = 32. No significant differences in other outcomes were observed.
Conclusion And Relevance: In this clinical trial, DRP prevention bundle in adjusted analysis decreased the rate of 30-day hospital readmission for any cause in patients who visited ED for a DRP.
Trial Registration: ClinicalTrials.gov (Identifier: NCT03607097).
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1177/10600280221143237 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Deep brain stimulation of the medial forebrain bundle promotes the extinction of active avoidance and is associated with mossy fibber sprouting in the hippocampus.
Behav Brain Res
December 2024
Departament de Biologia, Universitat de Girona, Girona, Spain. Electronic address:
Background: Post-traumatic stress disorder (PTSD) causes intrusive symptoms and avoidance behaviours due to dysregulation in various brain regions, including the hippocampus. Deep brain stimulation (DBS) shows promise for refractory PTSD cases. In rodents, DBS improves fear extinction and reduces anxiety-like behaviours, but its effects on active-avoidance extinction remain unexplored.
View Article and Find Full Text PDFPopliteal Neurovascular Bundle Medialization and Axial Flap Rotation to Avoid Bone Impingement in Tibial Turn-up Plasty: A Case Report.
Rev Bras Ortop (Sao Paulo)
November 2024
Departmento de Cirurgia Ortopédica, IRCCS Azienda Ospedaliera Universitaria di Bologna, Bolonha, Itália.
A 33-year-old male patient developed distal femur chronic osteomyelitis with massive bone loss after an open grade-3b fracture. Following several failed treatments to eradicate infection, a tibial turn-up procedure was performed to provide a stable and functional stump. To avoid neurovascular problems, the popliteal vessels and sciatic nerve were moved medially, and the flap was rotated externally to decrease the collapse.
View Article and Find Full Text PDFA staged approach to managing a combination of a terrible triad injury and an Essex-Lopresti fracture dislocation: an open forearm crush injury-a case report.
J Med Case Rep
December 2024
Department of Hand & Reconstructive Microsurgery Surgery, Rashid Hospital, Dubai, United Arab Emirates.
Background: Open and crushed forearm injury is a complex and rare injury affecting the upper extremity. It results in damage to various structures, including bones, soft tissues, and neurovascular bundles, ultimately leading to functional impairment. Typically, these injuries occur owing to high-energy trauma.
View Article and Find Full Text PDFComparison of leaf anatomical structure and photosynthetic characteristics between weedy rice and cultivated rice at the seedling stage.
Sci Rep
December 2024
College of Life Sciences, Henan Institute of Science and Technology, Xinxiang, Henan, China.
To explore the internal factors related to the strong growth and competitive ability of weedy rice during the seedling period, we collected two biotypes of Japonica weedy rice from Northeast China, four biotypes of Indica weedy rice from Eastern China and Southern China, and two biotypes of cultivated rice, Zhendao-8 (ZD-8) and Shanyou-63 (SY-63), which were used as controls in a pot experiment. Under homogeneous garden planting conditions, we measured the vascular bundle size (VBS), vascular bundle number (VBN), leaf thickness (LT), air cavity size (ACS), stomatal size (SS), stomatal density (SD), net photosynthetic rate (Pn) and stomatal conductance (Gs) of the weedy and cultivated rice biotypes. A comprehensive analysis was performed to explore the correlation between the seedling leaf structure and the photosynthetic indices of the biotypes.
View Article and Find Full Text PDFIntervention to Prevent Recurrent Intestinal Parasitic Infections in People Living with HIV in Selected Parts of Eastern Cape, South Africa.
Trop Med Infect Dis
November 2024
Department of Laboratory Medicine and Pathology, Walter Sisulu University, Mthatha 5100, South Africa.
Interactions between parasites and hosts are not fully understood, though the dynamic pattern of infection and reinfection in humans varies with different demographic variables and behavioral changes. A community-based non-equivalent control group post-test-only design, an aspect of quasi-experimental design (QED), was carried out between March 2019 and February 2020. For the extraction of data from respondents, structural questionnaires were filled.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!