Complicated Monkeypox Infection in a Patient With Multiple Sclerosis and Fingolimod Treatment.

Neurology

From the Departments of Neurology (L.M.-J., P.H., V.S.), and Infectious Diseases and Respiratory Medicine (H.K.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin; Berlin Institute of Health (P.H., L.M.J.), Charité-Universitätsmedizin Berlin; and private practice (K.A.), Berlin, Germany.

Published: April 2023

AI Article Synopsis

  • Fingolimod can cause low lymphocyte levels, which may increase the risk of severe monkeypox infections.
  • Recent monkeypox outbreaks have been classified as a Public Health Emergency of International Concern.
  • It's important to consider vaccinating multiple sclerosis (MS) patients before starting immunosuppressive treatments, especially those on sphingosine-1-phosphate receptor modulators like Fingolimod.

Article Abstract

Fingolimod-induced lymphopenia is a risk factor for severe monkeypox infection. As monkeypox was recently declared a Public Health Emergency of International Concern, vaccination should be evaluated in patients with MS before immunosuppressive treatment, particularly in patients receiving sphingosine-1-phosphate receptor modulators.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104614PMC
http://dx.doi.org/10.1212/WNL.0000000000206743DOI Listing

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