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Hearing Impairment in Oral Submucous Fibrosis: A Systematic Review.
Ear Nose Throat J
January 2025
Department of Dentistry, Zydus Medical College and Hospital, Dahod, Gujarat, India.
Article Synopsis
- Oral submucous fibrosis (OSMF) is a serious condition associated with areca nut chewing, linked to dental health and possibly hearing impairment, prompting a need for investigation into its effects on hearing.
- A systematic review of 1137 articles identified 18 studies showing a significant correlation between OSMF severity and hearing loss, particularly conductive hearing loss in advanced cases.
- The review highlighted that Eustachian tube dysfunction (ETD) often contributes to hearing issues in OSMF patients, emphasizing the importance of multidisciplinary management and early audiological screening for better patient outcomes.
Designing lysyl hydroxylase inhibitors for oral submucous fibrosis - Insights from molecular dynamics.
Int J Biol Macromol
December 2024
Center for Biotechnology, Anna University, Chennai 600 025, India. Electronic address:
Alpha-ketoglutarate (αKG) dependent Lysyl hydroxylase (LH) is a critical enzyme in the post-translational conversion of lysine into hydroxylysine in collagen triple helix and telopeptide regions. Overexpression of LH increases collagen hydroxylation and covalent cross-linkage, causing fibrosis. Currently, no drugs are available to inhibit LH potentially.
View Article and Find Full Text PDFP53 and Ki67 Biomarkers are Predictors for Malignant Transformation in Oral Submucous Fibrosis: A Prospective Study.
Asian Pac J Cancer Prev
December 2024
Department of Periodontology, HKDET'S Dental College, Hospital and Reaserch Institute, Humnadad, Karnataka, India.
Objectives: Oral submucous fibrosis (OSMF) is a potentially malignant disorder (PMD) characterized by a high rate of malignant transformation (MT). OSMF exhibits atrophic epithelium yet has a high proliferation rate. Both p53 and Ki67 are nuclear proteins associated with cell proliferation, detectable in the early stages of oral cancer (OC).
View Article and Find Full Text PDFAdipose-derived stem cell exosomes attenuates myofibroblast transformation via inhibiting autophagy through TGF-β/Smad2 axis in oral submucosal fibrosis.
J Nanobiotechnology
December 2024
Department of Oral & Maxillofacial Surgery, Xiangya Stomatological Hospital and Xiangya School of Stomatology, Central South University, Changsha, 410000, China.
Oral submucous fibrosis (OSF) is a precancerous condition that poses substantial health risks. OSF is mainly caused by betel nut chewing behavior, but its pathogenesis is still unclear and there is no effective treatment strategy. The transformation of fibroblasts to myofibroblast is the key pathological change in the development of OSF.
View Article and Find Full Text PDFCurcumin Alleviates Arecoline-induced Oral Submucous Fibrosis via the FOSL1/MAPK8 Axis.
Cell Biochem Biophys
December 2024
Department of Periodontal Mucosa, Changsha Stomatological Hospital, Changsha, Hunan, 410004, P.R. China.
Oral submucous fibrosis (OSF) is a precancerous lesion of the oral cavity. Areca nut consumption can cause OSF through sustained activation of buccal mucosal fibroblasts (BMFs). This study explored the effect of curcumin on arecoline-induced BMF activation and its mechanism of action.
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