AI Article Synopsis

  • The study aims to provide statistics on the prevalence and incidence of Mixed Connective Tissue Disease (MCTD) by using data from the Manhattan Lupus Surveillance Program (MLSP), which includes diverse populations with systemic lupus erythematosus (SLE) and related diseases.
  • MCTD cases were identified through rheumatology, hospitals, and databases, with specific criteria established for diagnosis, including positive RNP antibodies and certain clinical symptoms.
  • Results showed that the prevalence of MCTD varied significantly depending on the diagnostic criteria used, with the highest age-adjusted prevalence being 16.22 per 100,000 people, highlighting the complexities of defining MCTD in epidemiological research.

Article Abstract

Objective: Epidemiological data for MCTD are limited. Leveraging data from the Manhattan Lupus Surveillance Program (MLSP), a racially/ethnically diverse population-based registry of cases with SLE and related diseases including MCTD, we provide estimates of the prevalence and incidence of MCTD.

Methods: MLSP cases were identified from rheumatologists, hospitals and population databases using a variety of International Classification of Diseases, Ninth Revision codes. MCTD was defined as one of the following: fulfilment of our modified Alarcon-Segovia and Kahn criteria, which required a positive RNP antibody and the presence of synovitis, myositis and RP; a diagnosis of MCTD and no other diagnosis of another CTD; and a diagnosis of MCTD regardless of another CTD diagnosis.

Results: Overall, 258 (7.7%) cases met a definition of MCTD. Using our modified Alarcon-Segovia and Kahn criteria for MCTD, the age-adjusted prevalence was 1.28 (95% CI 0.72, 2.09) per 100 000. Using our definition of a diagnosis of MCTD and no other diagnosis of another CTD yielded an age-adjusted prevalence and incidence of MCTD of 2.98 (95% CI 2.10, 4.11) per 100 000 and 0.39 (95% CI 0.22, 0.64) per 100 000, respectively. The age-adjusted prevalence and incidence were highest using a diagnosis of MCTD regardless of other CTD diagnoses and were 16.22 (95% CI 14.00, 18.43) per 100 000 and 1.90 (95% CI 1.49, 2.39) per 100 000, respectively.

Conclusions: The MLSP provided estimates for the prevalence and incidence of MCTD in a diverse population. The variation in estimates using different case definitions is reflective of the challenge of defining MCTD in epidemiologic studies.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11068036PMC
http://dx.doi.org/10.1093/rheumatology/keac703DOI Listing

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