The first total syntheses of the orchid-derived natural products isoarundinin I (), (±)-bleochrin F ((±)-), (±)-blestanol K ((±)-), and (±)-pleionol ((±)-) from renewable starting materials are reported, along with the evaluation of their biological activities. The total syntheses were based on regioselective aromatic bromination reactions in combination with a key acid-promoted regioselective intramolecular cyclization. The biological results suggest that isoarundinin I (), (±)-blestanol K ((±)-), and (±)-pleionol ((±)-) have the potential to inhibit the growth of both sensitive and multidrug-resistant cancer cells.
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| http://dx.doi.org/10.1021/acs.jnatprod.2c00830 | DOI Listing |
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