AI Article Synopsis
- A new method has been developed to create C3-multifunctionalized α-hydroxy-β-amino pyridines using two different chiral catalysts, resulting in high yields and good enantioselectivity.
- The reaction occurs under mild conditions and is capable of accommodating a variety of functional groups.
- The final products exhibit selective antiosteosarcoma activity against 143B cancer cells, indicating potential therapeutic applications.
Article Abstract
An asymmetric catalytic approach for the construction of C3-multifunctionalization α-hydroxy-β-amino pyridines has been reported. The products can be accessed by the modulation of two chiral catalysts independently in high yield and with good enantioselectivity. The method features mild reaction conditions and an excellent functional group tolerance. Biological activity analysis shows that the resulting products have a selective antiosteosarcoma activity on 143B cells.
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| http://dx.doi.org/10.1021/acs.orglett.2c03987 | DOI Listing |
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Enantioselective Construction of C3-Multifunctionalization α-Hydroxy-β-amino Pyridines via α-Pyridyl Diazoacetate, Water, and Imines for Drug Hunting.
Org Lett
December 2022
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai 200062, China.
Article Synopsis
- A new method has been developed to create C3-multifunctionalized α-hydroxy-β-amino pyridines using two different chiral catalysts, resulting in high yields and good enantioselectivity.
- The reaction occurs under mild conditions and is capable of accommodating a variety of functional groups.
- The final products exhibit selective antiosteosarcoma activity against 143B cancer cells, indicating potential therapeutic applications.
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