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A Fleshy Mystery: Prurigo Nodularis.
Cureus
July 2024
Pathology, Louisiana State University (LSU) Health Shreveport/Rapides Regional Medical Center, Alexandria, USA.
Prurigo nodularis is a chronic dermatologic condition typically presenting as firm, dome-shaped pruritic nodules of various sizes that are often symmetrically distributed on extensor surfaces of the extremities. The diagnosis is clinical and based on a history of chronic, severe pruritis in the setting of characteristic, excoriated lesions. Treatment is difficult and aimed at reducing skin irritation and pruritus.
View Article and Find Full Text PDFPrurigo nodularis: new insights into pathogenesis and novel therapeutics.
Br J Dermatol
May 2024
Department of Dermatology.
Article Synopsis
- * The condition is influenced by specific inflammatory cytokines and neuropeptides, suggesting a complex interaction between the immune system and nerve signals that exacerbates symptoms.
- * Dupilumab is the first FDA-approved treatment for PN, with additional therapies like nemolizumab and various JAK inhibitors currently being researched for their effectiveness in managing the condition.
Molecular mechanisms of pruritus in prurigo nodularis.
Front Immunol
December 2023
Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.
Pruritus is the most common symptom of dermatological disorders, and prurigo nodularis (PN) is notorious for intractable and severe itching. Conventional treatments often yield disappointing outcomes, significantly affecting patients' quality of life and psychological well-being. The pathogenesis of PN is associated with a self-sustained "itch-scratch" vicious cycle.
View Article and Find Full Text PDFPrurigo nodularis (PN) is a quintessential neurocutaneous condition characterized by neural sensitization and intractable itch leading to intense scratching. This causes the formation of nodules with epidermal thickening and further release of pro-inflammatory mediators that recruit immune cells and increase dermal nerve proliferation and hypertrophy perpetuating the itch-scratch cycle. Those with PN have a significant quality-of-life (QoL) burden due to itch, anxiety, and sleep disturbance.
View Article and Find Full Text PDFSpontaneous resolution of intractable prurigo nodularis after subinsular cortex stroke.
JAAD Case Rep
February 2023
Department of Dermatology, University of California San Francisco, San Francisco, California.
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