AI Article Synopsis
- The study aimed to assess the long-term cognitive and executive function outcomes in preterm infants treated with erythropoietin or darbepoetin at 6 years old.
- Results showed that children who received ESAs had significantly higher IQ scores compared to those who received placebo, and their cognitive performance was comparable to healthy-term children.
- The findings suggest that ESAs could enhance long-term neurodevelopmental outcomes in preterm infants.
Article Abstract
Objective: We previously reported improved neurodevelopment at 2 and 4 years among preterm infants treated with erythropoietin or darbepoetin, known as erythropoiesis-stimulating agents (ESAs). We now characterize longitudinal outcomes through 6 years.
Methods: Children randomized to ESAs or placebo were evaluated at 6 years. Healthy-term children served as controls. Tests of cognition and executive function (EF) were performed.
Results: Cognitive/EF scores remained similar between 4 and 6 years within each group (ESA: 43 children; placebo: 17 children; term: 21 children). ESA recipients scored higher than placebo on Full-Scale IQ (94.2 ± 18.6 vs. 81.6 ± 16.7, p = 0.022), and Performance IQ (97.3 ± 16.2 vs. 81.7 ± 15.2, = 0.005). Aggregate EF trended better for the ESA group. Term controls scored better than placebo on all measures. ESA and term controls scored similarly on cognitive and EF tests.
Conclusion: ESA recipients had better outcomes than placebo recipients, and were similar to term children. ESAs may improve long-term cognition and executive function in preterm infants.
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Source |
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| http://dx.doi.org/10.2174/1573396319666221219114704 | DOI Listing |
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