After working in the substance use field for several years and conducting research on substance use, it has come to my attention how deeply ingrained the War on Drugs propaganda is in substance use research. The lines of research demonstrating the potential benefits of substance use (including illicit substances), delineation of harm from stigma, and the societal impact of the War on Drugs is rather weak and lacking, despite numerous recent studies showing the benefits of certain substances and reports of individuals in therapy and online suggesing that illicit substances help them in some respects. There are numerous critical implications of this bias in substance use research. Suppose the field primarily produces studies that show that all substances are harmful in almost any circumstance and that substance use disorders (SUDs) are primarily driven by psychological deficits (e.g., willpower). In that case, we, as researchers, would be feeding into the War on Drugs, which is known for marginalizing individuals, promoting organized crime, exacerbating SUDs, feeding into a police and prison state, and killing individuals due to tainted substances. Substance use researchers and clinicians are among the first to recognize that the War on Drugs has failed. Yet, despite this belief, we seem to have not quite fully noticed how the propaganda has influenced how we conduct our jobs and the research we produce. In the current letter, I inform researchers who study substance use and clinicians who treat SUDs to acknowledge their own learned biases against substances and those who use substances; to be more cautious when interpreting substance use data in the future.
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http://dx.doi.org/10.1177/00332941221146701 | DOI Listing |
Cureus
December 2024
Pediatric, Armed Forces Hospital Southern Region, Khamis Mushait, SAU.
Bernard-Soulier syndrome (BSS) is a rare autosomal recessive condition that is defined by low platelet count and platelet dysfunction characterized by the absence or dysfunction of the complex on the platelet surface. It is characterized by large defective platelets and thrombocytopenia. BSS is usually presented early in life.
View Article and Find Full Text PDFJ Control Release
January 2025
Changhai Clinical Research Unit, Shanghai Changhai Hospital, Naval Medical University, Shanghai 200433, China; Shanghai Key Laboratory of Nautical Medicine and Translation of Drugs and Medical Devices, Shanghai, China. Electronic address:
Gastric cancer is highly correlated with Helicobacter pylori (H. pylori) infection. Approximately 50 % of the population worldwide is infected with H.
View Article and Find Full Text PDFFront Pharmacol
January 2025
Centre for Molecular Biosciences, Ulster University, Coleraine, United Kingdom.
The WHO has compiled a list of pathogens that urgently require new antibiotics in response to the rising reports of antibiotic resistance and a diminished supply of new antibiotics. At the top of this list is fluoroquinolone-resistant , fluoroquinolone-resistant spp. and vancomycin-resistant .
View Article and Find Full Text PDFNervenarzt
January 2025
Abteilung für Molekulares Neuroimaging, Zentralinstitut für Seelische Gesundheit, Medizinische Fakultät Mannheim, Universität Heidelberg, 68159, Mannheim, Deutschland.
Background: Novel antidepressive substances are challenging the explanations for the mechanisms of action of traditional psychopharmacology.
Objective: What could be the shared effects of various antidepressants and in this context what role do extrapharmacological factors, such as the body and environment, play?
Material And Method: The available literature on clinical and preclinical data for assumed combined active factors of serotonergic psychedelic drugs, (es)ketamine, monoaminergic antidepressants and zuranolone are presented and the influence of context factors on the individual mechanisms of action is discussed.
Results: There are many indications that classical and novel pharmacological approaches could share similar mechanisms of action in the treatment of depression.
Clin Trials
January 2025
Department of Urology, University of Rochester Medical Center, Rochester, NY, USA.
Clinical trials of drugs, procedures, and other therapies play a crucial role in advancing medical science by evaluating the safety, efficacy, and optimal use of medical interventions. The design and implementation of these trials have evolved significantly over time, reflecting advancements in medicine, ethics, and methodology. Early historical examples, such as King Nebuchadnezzar II's and his captives' dietary experiment and Ambroise Paré's treatment of gunshot wounds, laid some foundational principles of trial design.
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