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| http://dx.doi.org/10.1186/s13756-022-01205-9 | DOI Listing |
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12-month neurological and psychiatric outcomes of semaglutide use for type 2 diabetes: a propensity-score matched cohort study.
EClinicalMedicine
August 2024
Department of Psychiatry, University of Oxford, Warneford Hospital, Warneford Lane, Oxford, OX3 7JX, United Kingdom.
Background: While semaglutide, approved for type-2 diabetes mellitus (T2DM), is being investigated as a treatment for brain disorders, concerns over adverse neuropsychiatric events have emerged. More data are therefore needed to assess the effects of semaglutide on brain health. This study provides robust estimates of the risk of neurological and psychiatric outcomes following semaglutide use compared to three other antidiabetic medications.
View Article and Find Full Text PDFOptimising deformity correction: a retrospective comparative analysis of two techniques in high magnitude curves in adolescent idiopathic scoliosis.
Asian Spine J
December 2024
Department of Spine Surgery, Bombay Hospital and Medical Research Centre, Mumbai, India.
Study Design: A retrospective comparative study.
Purpose: To validate the hypothesis that a combination of multilevel Ponte osteotomy (PO) with intraoperative traction (IOT) results in a better correction than IOT alone in high-magnitude curves in adolescent idiopathic scoliosis (AIS) and does not possess an attributable risk of neurological injury.
Overview Of Literature: On a comprehensive review of the literature, the choice of technique adopted for curves between 65° and 100° remains controversial with no major consensus favoring one technique over the other.
Development and evaluation of a simulation-based early-mobility curriculum for paediatric intensive care nurses.
Nurs Crit Care
January 2025
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Background: Early mobility is one strategy to reduce the harm from immobility that children experience in the paediatric intensive care unit (PICU). Early-mobility programmes rely on nurses, who currently perceive insufficient training as a barrier to mobilizing critically ill children. Nurses have identified simulation as a strategy to improve implementation of early-mobility protocols.
View Article and Find Full Text PDFDetection of Mycobacterium tuberculosis DNA in intraocular fluid of 11 suspected tuberculous uveitis patients by multiplex PCR.
BMC Ophthalmol
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Department of Tuberculosis, New District Branch of Northern Jiangsu People's Hospital of Jiangsu Province, Yangzhou, 225001, Jiangsu Province, China.
Background: This study aims to detect Mycobacterium tuberculosis complex (MTBC) DNA in intraocular fluid from clinically suspected tuberculous uveitis patients using multiplex polymerase chain reaction (PCR) and investigate the diagnostic utility of multiplex PCR for tuberculous uveitis.
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A multiplex method for rapidly identifying viral protease inhibitors.
Mol Syst Biol
January 2025
Department of Pathology and Cell Biology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, 10032, USA.
With current treatments addressing only a fraction of pathogens and new viral threats constantly evolving, there is a critical need to expand our existing therapeutic arsenal. To speed the rate of discovery and better prepare against future threats, we establish a high-throughput platform capable of screening compounds against 40 diverse viral proteases simultaneously. This multiplex approach is enabled by using cellular biosensors of viral protease activity combined with DNA-barcoding technology, as well as several design innovations that increase assay sensitivity and correct for plate-to-plate variation.
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