Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s12630-022-02352-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Maternal exposure to general anesthesia and labor epidural analgesia during pregnancy and delivery, and subsequent neurodevelopmental outcomes in children.
Int J Obstet Anesth
December 2024
Department of Anesthesiology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA; Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA. Electronic address:
Temporal ablation of the ciliary protein IFT88 alters normal brainwave patterns.
Sci Rep
January 2025
Department of Molecular, Cellular, and Biomedical Sciences, College of Life Sciences and Agriculture, University of New Hampshire, Durham, NH, 03824, USA.
Article Synopsis
- The primary cilium is a crucial organelle involved in various signaling pathways, and its dysfunction is linked to conditions like Bardet-Biedl syndrome, Alzheimer's, and autism, all of which can lead to cognitive impairment.
- Researchers studied the effects of temporarily disabling the IFT88 gene, vital for cilia formation, in adult mice to understand cilia's role in brain activity.
- The findings showed that mice lacking functional cilia had significant learning deficits and abnormal brainwave patterns, emphasizing the importance of primary cilia for proper neural function and memory in adults.
A cross-tissue transcriptome-wide association study identifies new susceptibility genes for insomnia.
J Neurophysiol
February 2025
Department of Anesthesiology, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, People's Republic of China.
Article Synopsis
- Insomnia has a genetic component (22-25% heritability), but key genetic regions influencing its risk are not well understood.
- Researchers utilized advanced methods like UTMOST and TWAS, combined with data from a large GWAS of over 462,000 Europeans and gene expression data, to study insomnia-related genes.
- The study identified two new susceptibility genes (VRK2 and MMRN1) linked to insomnia, found specific brain regions enriched with related SNPs, and highlighted important biological pathways that could lead to future treatment options.
Comprehensive Analysis of Bulk RNA-Seq and Single-Cell RNA-Seq Data Unveils Sevoflurane-Induced Neurotoxicity Through SLC7A11-Associated Ferroptosis.
J Cell Mol Med
December 2024
Department of Critical Care Medicine, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, P. R. China.
Sevoflurane's potential impact on cognitive function and neurodevelopment, especially in susceptible populations such as infants and the elderly, has raised widespread concern. This study focuses on how sevoflurane induces ferroptosis in astrocytes and identifies solute carrier family 7 member 11 (SLC7A11) as a mediator of ferroptosis, providing new insights into sevoflurane-related neurotoxic pathways. We analysed single-cell sequencing (scRNA-seq) data from sevoflurane-exposed mice and control mice, supplemented with bulk RNA-seq data, to assess gene expression alterations.
View Article and Find Full Text PDFMicroglial Depletion, a New Tool in Neuroinflammatory Disorders: Comparison of Pharmacological Inhibitors of the CSF-1R.
Glia
December 2024
Inserm, NeuroDiderot, Université Paris-Cité, Paris, France.
A growing body of evidence highlights the importance of microglia, the resident immune cells of the CNS, and their pro-inflammatory activation in the onset of many neurological diseases. Microglial proliferation, differentiation, and survival are highly dependent on the CSF-1 signaling pathway, which can be pharmacologically modulated by inhibiting its receptor, CSF-1R. Pharmacological inhibition of CSF-1R leads to an almost complete microglial depletion whereas treatment arrest allows for subsequent repopulation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!