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Beyond neutralization: Fc-dependent antibody effector functions in SARS-CoV-2 infection. | LitMetric

Beyond neutralization: Fc-dependent antibody effector functions in SARS-CoV-2 infection.

Nat Rev Immunol

Michael G. DeGroote Institute for Infectious Disease Research, McMaster Immunology Research Centre, Department of Biochemistry & Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.

Published: June 2023

AI Article Synopsis

Article Abstract

Neutralizing antibodies are known to have a crucial role in protecting against SARS-CoV-2 infection and have been suggested to be a useful correlate of protection for vaccine clinical trials and for population-level surveys. In addition to neutralizing virus directly, antibodies can also engage immune effectors through their Fc domains, including Fc receptor-expressing immune cells and complement. The outcome of these interactions depends on a range of factors, including antibody isotype-Fc receptor combinations, Fc receptor-bearing cell types and antibody post-translational modifications. A growing body of evidence has shown roles for these Fc-dependent antibody effector functions in determining the outcome of SARS-CoV-2 infection. However, measuring these functions is more complicated than assays that measure antibody binding and virus neutralization. Here, we examine recent data illuminating the roles of Fc-dependent antibody effector functions in the context of SARS-CoV-2 infection, and we discuss the implications of these data for the development of next-generation SARS-CoV-2 vaccines and therapeutics.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9761659PMC
http://dx.doi.org/10.1038/s41577-022-00813-1DOI Listing

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