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Associations Between Contrast Sensitivity, Optical Coherence Tomography Features and Progression From Intermediate to Late Age-related Macular Degeneration.
Am J Ophthalmol
November 2024
From the Harvard Retinal Imaging Lab (C.B., F.R., F.V., M.G., X.D., A.B., I.P., I.S., K.O., G.B., I.G., J.R., I.L., L.A. K., and J.B.M.), Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA; Department of Ophthalmology (F.R., X.D., D.N., G.B., R.B., I.L., L.A. K., D.V., D.H., J.W.M., and J.B. M.), Retina Service, Massachusetts Eye and Ear, Boston, Massachusetts, USA. Electronic address:
Article Synopsis
- This study explores the relationships between OCT biomarkers and contrast sensitivity in eyes diagnosed with intermediate age-related macular degeneration (iAMD), aiming to improve understanding of disease progression.
- A total of 205 eyes from 134 patients were analyzed; findings reveal that higher retinal pigment epithelium volume and intraretinal hyperreflective foci correlate with poorer contrast sensitivity measures.
- Over a follow-up period, approximately 43% of eyes progressed to late-stage AMD, indicating the potential clinical significance of the identified biomarkers in predicting progression.
Topographic and quantitative correlation of structure and function using deep learning in subclinical biomarkers of intermediate age-related macular degeneration.
Sci Rep
November 2024
Laboratory for Ophthalmic Image Analysis (OPTIMA), Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria.
To examine the morphological impact of deep learning (DL)-quantified biomarkers on point-wise sensitivity (PWS) using microperimetry (MP) and optical coherence tomography (OCT) in intermediate AMD (iAMD). Patients with iAMD were examined by OCT (Spectralis). DL-based algorithms quantified ellipsoid zone (EZ)-thickness, hyperreflective foci (HRF) and drusen volume.
View Article and Find Full Text PDFAssociation of subretinal drusenoid deposits and cardiovascular disease.
Sci Rep
October 2024
Ophthalmology Department, Hadassah Medical Center, Jerusalem, Israel.
Article Synopsis
- * A total of 597 AMD patients were analyzed, with 332 having SDDs and 265 without, using optical coherence tomography (SD-OCT) and reviewing electronic medical records.
- * Results showed that AMD patients with SDDs are significantly more likely to be diagnosed with CVD and have procedures such as percutaneous transluminal coronary angioplasty (PTCA), suggesting a possible shared mechanism between SDDs and severe cardiovascular conditions.
Rheumatic fever and long-term use of benzathine penicillin as possible risk factors for extensive macular atrophy with pseudodrusen in a Brazilian cohort.
Int J Retina Vitreous
October 2024
Hospital De Olhos Do Paraná, 483, Presidente Taunay St. Alameda Presidente Taunay, 483 Batel, Curitiba, CEP 80420-180, PR, Brazil.
Article Synopsis
- - The study investigated the correlation between rheumatic fever (RF) history and benzathine penicillin (BP) treatment with extensive macular atrophy with pseudodrusen (EMAP) in Brazilian patients through a retrospective, observational case-control approach.
- - Out of 77 patients (66.2% women, average age 58.6), a significant majority had a history of RF (90.9%) and BP treatment (94.8% starting at an average age of 7.3 years with an 11.8-year duration).
- - Results showed that longer BP treatment duration was linked to a decrease in atrophic area, while older age at RF diagnosis influenced the likelihood of subretinal dr
Abetalipoproteinemia with angioid streaks, choroidal neovascularization, atrophy, and extracellular deposits revealed by multimodal retinal imaging.
Ophthalmic Genet
December 2024
Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.
Article Synopsis
- - Abetalipoproteinemia (ABL) is a rare genetic disorder characterized by the absence of certain lipoproteins due to a defective triglyceride transfer protein, impacting the retina and leading to vision problems, including conditions resembling retinitis pigmentosa.
- - Multimodal retinal imaging was conducted on two ABL patients, revealing significant eye changes like choroidal neovascularization and deposits in the retina, alongside a range of vision loss.
- - The study suggests that mutations in the MTTP gene within the retina may contribute to ABL-related eye diseases, highlighting the importance of ongoing eye care for affected individuals, particularly to manage treatable conditions like choroidal neovascularization.
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