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Recurrent Achilles Tendon Rupture in Multiple Sites as a Primary Manifestation of Systemic Lupus Erythematosus in a 32-Year-Old Patient: A Case Report.
Cureus
May 2024
Orthopaedic Surgery, Hospital Star Médica Aguascalientes, Aguascalientes, MEX.
The Achilles tendon is vital for walking and running, but it's also the most frequently ruptured tendon. Ruptures often occur without direct trauma and present with acute posterior ankle/heel pain. Various factors like age, biomechanical properties, degeneration, and mechanical factors influence susceptibility to rupture.
View Article and Find Full Text PDFRadiologic and histopathologic effects of favipiravir and hydroxychloroquine on fracture healing in rats.
Naunyn Schmiedebergs Arch Pharmacol
October 2024
Department of Orthopedics and Traumatology, Faculty of Medicine, Duzce University, 81000, Duzce, Turkey.
Article Synopsis
- Fracture healing involves complex interactions among physical, biological, and chemical factors, and although research is growing, its mechanism is not completely understood.
- This study examined the effects of the COVID-19 treatments favipiravir and hydroxychloroquine on fracture healing using 48 male Wistar rats, which were analyzed at the 2nd and 4th weeks for radiological and histological changes.
- Results showed a significant early negative impact of favipiravir on bone repair, but potential positive effects later on, while hydroxychloroquine did not significantly influence fracture healing.
Targeted inhibition of autophagy in hepatic stellate cells by hydroxychloroquine: An effective therapeutic approach for the treatment of liver fibrosis.
Liver Int
August 2024
Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an, China.
Background And Purpose: Liver fibrosis is a wound-healing reaction which is the main cause of chronic liver diseases worldwide. The activated hepatic stellate cell (aHSC) is the main driving factor in the development of liver fibrosis. Inhibiting autophagy of aHSC can prevent the progression of liver fibrosis, but inhibiting autophagy of other liver cells has opposite effects.
View Article and Find Full Text PDFMedical Management to Treat Chronic Non-healing Ulcers: A Case Series.
Cureus
January 2024
Radiology, Cardiff Health Centre, Manarcad, IND.
Introduction: Chronic non-healing leg ulcers are skin defects below the knee that resist healing for more than six weeks. They cause physical, emotional, and economic burdens to patients and society.
Objectives: To introduce an innovative medical strategy that targets the chronic inflammation component in non-healing ulcers (NHUs) with rheumatic features and to evaluate its potential effectiveness in achieving complete healing.
The effects of hydroxychloroquine-induced oxidative stress on fracture healing in an experimental rat model.
Jt Dis Relat Surg
January 2024
Sağlık Bilimleri Üniversitesi, Başakşehir Çam ve Sakura Şehir Hastanesi, Ortopedi ve Travmatoloji Anabilim Dalı, İstanbul, Türkiye.
Objectives: The purpose of this study was to investigate whether hydroxychloroquine (HCQ) sulfate causes oxidative stress (OS) and its effect on fracture healing in an experimental rat model.
Materials And Methods: In this experimental study, open diaphyseal femur fractures were induced in 24 eight-week-old male rats (mean weight: 225±25 g; range, 200 to 250 g) and then fixed with K-wire. The rats were divided into four groups: HCQ-2, control-2 (C-2), HCQ-4, and control-4 (C-4).
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