AI Article Synopsis
- * Sometimes, paediatric-type gliomas can appear in younger adults, and adult-type gliomas can occur in children, blurring the lines between these categories.
- * The text reviews newly identified low-grade paediatric gliomas and suggests a comprehensive diagnostic method to differentiate these unique tumor types according to WHO guidelines.
Article Abstract
The WHO 2021 classification of central nervous system cancers distinguishes diffuse gliomas that arise in adults (referred to as the "adult type") and those that arise in children (defined as "paediatric") based on clinical and molecular characteristics."). However, paediatric-type gliomas may occasionally be present in younger adults and occasionally adult-type gliomas may occur in children. Diffuse low-grade paediatric glioma includes diffuse astrocytoma altered by MYB or MYBL1, low-grade polymorphic juvenile neuroepithelial tumour, angiocentric glioma, and diffuse low-grade glioma with an altered MAPK pathway. Here, we examine these newly recognised entities according to WHO diagnostic criteria and propose an integrated diagnostic approach that can be used to separate these clinically and biologically distinct tumor groups.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763978 | PMC |
| http://dx.doi.org/10.32074/1591-951X-828 | DOI Listing |
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