A type II polyketide synthase biosynthetic gene cluster () containing three P450 genes was identified from a soil metagenomic library, and novel benz[]isoquinoline-desferrioxamine B conjugated compound amodesmycins were isolated from J1074 harboring the gene cluster. Genetic evidence showed that the benz[]isoquinoline part and desferrioxamine B part in amodesmycins were derived from the gene cluster and J1074, respectively, while P450 enzymes played critical roles in the conjunction of these two parts.
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| http://dx.doi.org/10.1021/acs.orglett.2c03788 | DOI Listing |
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