Introduction/aims: Nerve ultrasound is useful in the diagnosis and follow-up of peripheral nerve disorders in children. The aim of this study was to explore and analyze the current literature on nerve cross-sectional area (CSA) in healthy children, with the goal of presenting reference values and discussing their implications.
Methods: We performed a systematic review and meta-analysis of studies that reported ultrasound measurements of the upper or lower limb nerves in healthy children through a search of Web of Science, PubMed, Embase, and Scopus.
Results: Sixteen studies with measurements of 10 nerves covering a total of 5149 nerves measured in 823 healthy children (445 boys and 378 girls) were included. Mean nerve CSA increased with age in the median nerve at the middle and lower third of the upper arm, mid-forearm, and distal wrist crease, the ulnar nerve at the middle third of the upper arm and elbow, the radial nerve at the spiral groove, and the tibial nerve at the popliteal fossa. Growth charts for nerve CSA for different age groups were developed.
Discussion: This meta-analysis provides robust reference values for nerve CSA at different sites in children, and this can inform clinical practice and assist in identifying nerve enlargement. Moreover, it identifies the strength and quality of the current published data. We recommend future studies divide their samples into smaller age subgroups and standardize the anatomic site of measurement.
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http://dx.doi.org/10.1002/mus.27773 | DOI Listing |
Fluids Barriers CNS
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January 2025
Graduate Program in Electrical and Computer Engineering, Universidade Tecnológica Federal do Paraná (UTFPR), Curitiba, 80230-901, Brazil.
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January 2025
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View Article and Find Full Text PDFThe increasing availability of coarse-scale climate simulations and the need for ready-to-use high-resolution variables drive the climate community to the challenge of reducing computational resources and time for downscaling purposes. To this end, statistical downscaling is gaining interest as a potential strategy for integrating high-resolution climate information obtained through dynamical downscaling over limited years, providing a clear understanding of the gains and losses in combining dynamical and statistical downscaling. In this regard, several questions can be raised: (i) what is the performance of statistical downscaling, assuming dynamical downscaling as a reference over a shared time window; (ii) how much the performance of statistical downscaling is affected by changes in the number of years available for training; (iii) how does the climate normal considered for the training affect the predictions.
View Article and Find Full Text PDFClin Chem Lab Med
January 2025
Department of Pathology and Laboratory Medicine, Canadian Microbiology Proficiency Testing Program (CMPT), University of British Columbia, Vancouver, Canada.
External quality assessment (EQA) cycles are the smallest complete units within EQA programs that laboratories can use to obtain external assessments of their performance. In each cycle, several samples are distributed to the laboratories registered for participation, and ideally, EQA programs not only cover the examination procedures but also the pre- and post-examination procedures. The properties and concentration range of measurands in individual samples are selected with regard to the intended challenge for the participants so that each sample fulfils its purpose.
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