The effects of polyphenols against oxidative stress in are determined by coexisting bacteria.

Front Nutr

Grupo de Investigación en Polifenoles (GIP-USAL), Universidad de Salamanca, Salamanca, Spain.

Published: December 2022

AI Article Synopsis

  • Gut microbiota significantly influences human health, including immune and metabolic functions, and diet components like polyphenols can modify gut microbiota for health benefits.
  • A study assessed how flavonoids (quercetin or epicatechin) and specific probiotic strains affected worms' resistance to oxidative stress, finding that only the combination of both enhanced stress resistance.
  • Results suggest that while bacteria and polyphenols interact to improve oxidative stress resistance, additional mechanisms beyond just bacterial metabolism of polyphenols are also involved.

Article Abstract

Introduction: Increasing evidence supports the role of gut microbiota in many aspects of human health, including immune, metabolic and neurobehavioral traits. Several studies have focused on how different components of the diet, such as polyphenols, can modulate the composition and function of the gut microbiota leading to health benefits.

Methods: The effects on the resistance against thermally induced oxidative stress of grown in the presence of flavonoids (quercetin or epicatechin) and fed different probiotic strains, namely CLC17, NCIMB 8809 and CECT 410, were explored.

Results: Feeding with the assayed bacteria in the absence of flavonoids did not significantly affect body size and fertility of the worms neither improve their resistance against oxidative stress compared to controls. However, increased resistance to stress was found when was cultivated in the presence of both and flavonoids, but not with or . An exploratory study revealed the presence of glycosylated and sulfated metabolites together with the aglycone in worms treated with quercetin and fed any of the different assayed LAB strains. However, in the assays with epicatechin a differential metabolite, tentatively identified as 5-(4'-hydroxyphenyl)-γ-valerolactone 3'--glucoside, was detected in the worms fed but not with the other bacteria.

Conclusion: The obtained results indicated that the interactions bacteria/polyphenol play a key role in the effects produced in regarding resistance against oxidative stress, although those effects cannot be only explained by the ability of bacteria to metabolize polyphenols, but other mechanisms should also be involved.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9752899PMC
http://dx.doi.org/10.3389/fnut.2022.989427DOI Listing

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