AI Article Synopsis
- The study aimed to compare the anatomical presentation and severity of colonic diverticulosis between African Caribbeans (AC) and Europeans (E) in a controlled study involving 274 patients with lower gastrointestinal hemorrhage in France.
- Results showed that AC patients had consistently poorer hemodynamic conditions and required more blood transfusions compared to E patients, with AC exhibiting a higher prevalence of pancolonic diverticulosis while E had left-sided diverticulosis.
- The findings suggest that genetic factors may play a larger role in the anatomical differences observed in diverticulosis between the two groups, rather than environmental influences or dietary habits.
Article Abstract
Background: Diverticulosis is not well characterized in the Caribbeans. Our aim was to compare the anatomical presentation of colonic diverticulosis in African Caribbeans (group AC) versus Europeans (group E) and severity.
Methods: We conducted a prospective controlled study involving 274 patients admitted for lower gastrointestinal haemorrhage (LGIH) in France (center 1: Guadeloupe; center 2: La Roche-sur-Yon); 179 cases with diverticular haemorrhage, including 129 in group AC and 40 in group E. Exploration of the colon included a detailed assessment of diverticula using a dedicated endoscopic grid.
Results: AC and E had similar characteristics in terms of age, gender, previous history of LGIH, body mass index, dietary habits, and medications, but AC had significantly poorer hemodynamic parameters at admission and required more blood transfusions (66.7% vs. 42.5%; =0.01) during hospitalization. Out of the 169 patients included in the study, a complete exploration of the colon was achieved in 81% ( = 137) (AC, = 106; E, = 31), and revealed right-side diverticulosis in AC (in 90.6%, included into a pancolonic form in 73.6% vs. 35.5%; =0.0002) and left-side diverticulosis in E (in 96.8%, isolated form in 58.1% vs. 9.4%, =0.0002). These data were confirmed by a sensitivity analysis using an endoscopic grid in 92 patients, achieving a higher frequency and larger size of diverticula in AC.
Conclusion: Our study has shown that diverticulosis was pancolonic in AC and more frequently associated with more severe haemorrhage than the left-sided diverticulosis of Europeans. This anatomical presentation may be driven by the genetic background more than the environment and diet.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750784 | PMC |
| http://dx.doi.org/10.1155/2022/8360837 | DOI Listing |
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