We investigate the problem of statistical analysis of interval-valued time series data - two nonintersecting real-valued functions, representing lower and upper limits, over a period of time. Specifically, we pay attention to the two concepts of phase (or horizontal) variability and amplitude (or vertical) variability, and propose a phase-amplitude separation method. We view interval-valued time series as elements of a function (Hilbert) space and impose a Riemannian structure on it. We separate phase and amplitude variability in observed interval functions using a metric-based alignment solution. The key idea is to map an interval to a point in , view interval-valued time series as parameterized curves in , and borrow ideas from elastic shape analysis of planar curves, including PCA, to perform registration, summarization, analysis, and modeling of multiple series. The proposed phase-amplitude separation provides a new way of PCA and modeling for interval-valued time series, and enables shape clustering of interval-valued time series. We apply this framework to three different applications, including finance, meteorology and physiology, proves the effectiveness of proposed methods, and discovers some underlying patterns in the data. Experimental results on simulated data show that our method applies to the point-valued time series.
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http://dx.doi.org/10.1080/02664763.2021.1981257 | DOI Listing |
Genet Med
January 2025
Newborn Screening Ontario, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada; Children's Hospital of Eastern Ontario Research Institute, University of Ottawa, Ottawa. Electronic address:
Purpose: Universal newborn hearing screening (UNHS) programs using audiometric techniques alone are limited in ability to detect non-congenital childhood permanent hearing loss (PHL). In 2019, Ontario launched universal newborn screening (NBS) for PHL risk factors: congenital cytomegalovirus (cCMV) and 22 common variants in GJB2 and SLC26A4. Here we describe our experience with genetic risk factor screening.
View Article and Find Full Text PDFCancer Med
January 2025
Division of Gastroenterology and Nephrology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan.
Background And Aim: In recent years, there has been a rise in cryptogenic hepatocellular carcinoma (c-HCC) cases in Japan, posing a detection challenge due to an unknown etiology. This study aims to enhance diagnostic strategies for c-HCC by analyzing its characteristics and exploring current opportunities for detection.
Methods: A retrospective study was conducted from April 2012 to March 2022, enrolling 372 newly diagnosed hepatocellular carcinoma (HCC) patients.
Circ Genom Precis Med
January 2025
Department of Medicine, Division of Cardiology (M.P., N.J.P., N.P.S.), Duke University, Durham, NC.
Background: Established risk models may not be applicable to patients at higher cardiovascular risk with a measured Lp(a) (lipoprotein[a]) level, a causal risk factor for atherosclerotic cardiovascular disease.
Methods: This was a model development study. The data source was the Nashville Biosciences Lp(a) data set, which includes clinical data from the Vanderbilt University Health System.
Pharm Stat
January 2025
Department of Anesthesia, University of Iowa, Iowa City, Iowa, USA.
With contemporary anesthetic drugs, the efficacy of general anesthesia is assured. Health-economic and clinical objectives are related to reductions in the variability in dosing, variability in recovery, etc. Consequently, meta-analyses for anesthesiology research would benefit from quantification of ratios of standard deviations of log-normally distributed variables (e.
View Article and Find Full Text PDFMagn Reson Med
January 2025
MR Physics, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Purpose: MR-based FID navigators (FIDnavs) do not require gradient pulses and are attractive for prospective motion correction (PMC) due to short acquisition times and high sampling rates. However, accuracy and precision are limited and depend on a separate calibration measurement. Besides FIDnavs, stationary NMR field probes are also capable of measuring local, motion-induced field changes.
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