Liquid-liquid separation is crucial in the present circumstances. Substitution of the conventional types of separation like distillation and pervaporation is mandatory due to the high energy requirement of the two. The separation of organic mixtures has a huge potential in industries such as pharmaceutical, fine chemicals, fuels, textile, papers, and fertilizers. Membrane-affiliated separations are one of the prime techniques for liquid-liquid separations. Organic solvent nanofiltration, solvent-resistant nanofiltration, and ultrafiltration are a few methods through which organic liquid-liquid separation can be attained. Implementation of such a technology in chemical industries reduces the time consumption and is cost efficient. Even though a lot of research has been done, attention is needed in the field of organic-liquid separation aided by membranes. In this review, various membranes used for organic mixture separations such as polar-nonpolar, polar-polar, and nonpolar-nonpolar are discussed with a focus on membrane materials, additives, separation theory, separation type, experimental setup, fouling mitigation, surface modification, and major challenges. The review also offers insights and probable solutions for existing problems and also discusses the scope of research to be undertaken in the future.
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http://dx.doi.org/10.1021/acsomega.2c02885 | DOI Listing |
Pharm Res
January 2025
Solid State Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, 835215, Jharkhand, India.
Improving the bioavailability of poorly water-soluble drugs presents a significant challenge in pharmaceutical development. Amorphous solid dispersions (ASDs) have garnered substantial attention for their capability to augment the solubility and dissolution rate of poorly water-soluble drugs, thereby markedly enhancing their bioavailability. ASDs, characterized by a metastable equilibrium where the active pharmaceutical ingredient (API) is molecularly dispersed, offer enhanced absorption compared to crystalline forms.
View Article and Find Full Text PDFJ Phys Chem Lett
January 2025
Centre of High Field NMR Spectroscopy and Imaging, Nanyang Technological University, 21 Nanyang Link, Singapore 637371.
The relationship among protein structure, function, and dynamics is fundamental to biological activity, particularly in more complex biomolecular systems. Solid-state and solution-state NMR techniques offer powerful means to probe these dynamics across various time scales. However, standard assumptions about molecular motion are often challenged in phase-separated systems like phosphorylated heterochromatin protein 1 alpha (pHP1α), which exhibit both solid- and solution-like characteristics.
View Article and Find Full Text PDFFront Microbiol
January 2025
UPR4301 Centre de Biophysique Moléculaire (CBM), Orléans, France.
We investigated the metabolome of the iron- and sulfur-oxidizing, extremely thermoacidophilic archaeon grown on mineral pyrite (FeS). The extraction of organic materials from these microorganisms is a major challenge because of the tight contact and interaction between cells and mineral materials. Therefore, we applied an improved protocol to break the microbial cells and separate their organic constituents from the mineral surface, to extract lipophilic compounds through liquid-liquid extraction, and performed metabolomics analyses using MALDI-TOF MS and UHPLC-UHR-Q/TOF.
View Article and Find Full Text PDFPlant Biotechnol J
January 2025
Center for Plant Water-use and Nutrition Regulation and College of JunCao Science and Ecology, Joint International Research Laboratory of Water and Nutrient in Crop, Fujian Agriculture and Forestry University, Fuzhou, China.
Heat stress significantly impacts global rice production, highlighting the critical need to understand the genetic basis of heat resistance in rice. U2AF (U2 snRNP auxiliary factor) is an essential splicing complex with critical roles in recognizing the 3'-splice site of precursor messenger RNAs (pre-mRNAs). The U2AF small subunit (U2AF35) can bind to the 3'-AG intron border and promote U2 snRNP binding to the branch-point sequences of introns through interaction with the U2AF large subunit (U2AF65).
View Article and Find Full Text PDFAdv Sci (Weinh)
January 2025
State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Biomolecular condensates segregate nuclei into discrete regions, facilitating the execution of distinct biological functions. Here, it is identified that the WW domain containing adaptor with coiled-coil (WAC) is localized to nuclear speckles via its WW domain and plays a pivotal role in regulating alternative splicing through the formation of biomolecular condensates via its C-terminal coiled-coil (CC) domain. WAC acts as a scaffold protein and facilitates the integration of RNA-binding motif 12 (RBM12) into nuclear speckles, where RBM12 potentially interacts with the spliceosomal U5 small nuclear ribonucleoprotein (snRNP).
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