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A Tale of Two Medicines: The Need for Ownership, End-to-End Planning and Execution for Development and Introduction of Maternal Health Medicines.
Int J MCH AIDS
September 2024
Concept Foundation, Avenue de Sécheron, Geneva, Switzerland.
Article Synopsis
- - Postpartum hemorrhage (PPH) is a leading cause of maternal death in low- and middle-income countries (LMICs), and the WHO recommends heat-stable carbetocin and tranexamic acid to prevent and treat it.
- - Implementation of these recommended drugs is hindered by issues like disorganized procurement, poor quality control, and limited access in many LMICs.
- - Despite having safety and efficacy data, access challenges differ between the two drugs, necessitating coordinated actions for better availability of essential maternal health commodities.
Skull Base Chordoma in a Young Lady - A Tale of Mismanagement and Redemption: A Case Report and Review of Literature.
Indian J Otolaryngol Head Neck Surg
October 2024
Department of Head and Neck Surgery, Dr B Borooah Cancer Institute, Guwahati, India.
Skull base chordomas are a rare entity that requires multidisciplinary decision-making for management. We report a case wherein the patient was initially mismanaged at a peripheral centre, and was then redeemed by a multidisciplinary tumor board decision-making and specialized surgical procedures. We also present a brief review of the therapeutic options.
View Article and Find Full Text PDFPlexiform's perplexities: a tale of two plexiform neurofibromas.
J Surg Case Rep
August 2024
Department of Medicine, Dr. DY Patil Hospital and Research Centre, Nerul, Navi Mumbai, Maharashtra 400706, India.
Plexiform neurofibroma (PF) is a rare benign variant belonging to a subtype of neurofibromatosis type 1 that forms bulging or deforming masses arising from the peripheral nerve sheath. These masses involve surrounding connective tissue or dermal layers, leading to multiple cutaneous changes and certain characteristic appearances. It is these appearances that aid in the diagnosis of PF.
View Article and Find Full Text PDFArticle Synopsis
- Myositis is a rare autoimmune disorder causing chronic muscle inflammation, leading to weakness, fatigue, and pain, with possible complications in other organs like the gastrointestinal tract.
- The case series discusses two patients with polymyositis and dermatomyositis who experienced dysphagia (difficulty swallowing) as a complication, which required specialized assessments and treatments.
- Effective management included intravenous immunoglobulin, immunosuppressants, and lifestyle changes, underscoring the need for a collaborative, personalized approach in treating myositis-related upper GI issues for better patient outcomes.
Coexistence of BCR∷ABL1 translocation and JAK2V617F mutations in indian patients with myeloproliferative neoplasms: A case series.
Indian J Pathol Microbiol
July 2024
Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, Punjab, India.
BCR∷ABL1 translocation and JAK2V617F mutations are canonical variants of myeloproliferative neoplasms (MPNs). Traditionally considered mutually exclusive, they may rarely coexist. We report the clinicopathological profile and treatment outcomes of four MPN patients with coexistence of these disease-defining genetic variants.
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