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| http://dx.doi.org/10.1016/j.iccn.2022.103372 | DOI Listing |
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The pentose phosphate pathway controls oxidative protein folding and prevents ferroptosis in chondrocytes.
Nat Metab
January 2025
Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.
Bone lengthening and fracture repair depend on the anabolic properties of chondrocytes that function in an avascular milieu. The limited supply of oxygen and nutrients calls into question how biosynthesis and redox homeostasis are guaranteed. Here we show that glucose metabolism by the pentose phosphate pathway (PPP) is essential for endochondral ossification.
View Article and Find Full Text PDFCell cycle progression of under-replicated cells.
Nucleic Acids Res
January 2025
Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, 6565 MD Anderson Blvd, Houston, TX 77030, USA.
Cell cycle checkpoints are the regulatory mechanisms that secure the strict order of cellular events for cell division that ensure genome integrity. It has been proposed that mitosis initiation depends on the completion of DNA replication, which must be tightly controlled to guarantee genome duplication. Contrary to these conventional hypotheses, we showed here that cells were able to enter mitosis without completion of DNA replication.
View Article and Find Full Text PDFThe Impact of Artificial Intelligence on Healthcare: A Comprehensive Review of Advancements in Diagnostics, Treatment, and Operational Efficiency.
Health Sci Rep
January 2025
Department of Microbiology Dr D. Y. Patil Medical College, Hospital and Research Centre, Dr D. Y. Patil Vidyapeeth (Deemed-to-be-University) Pune Maharashtra India.
Background And Aims: Artificial Intelligence (AI) beginning to integrate in healthcare, is ushering in a transformative era, impacting diagnostics, altering personalized treatment, and significantly improving operational efficiency. The study aims to describe AI in healthcare, including important technologies like robotics, machine learning (ML), deep learning (DL), and natural language processing (NLP), and to investigate how these technologies are used in patient interaction, predictive analytics, and remote monitoring. The goal of this review is to present a thorough analysis of AI's effects on healthcare while providing stakeholders with a road map for navigating this changing environment.
View Article and Find Full Text PDFBidimensionally partitioned online sequential broad learning system for large-scale data stream modeling.
Sci Rep
December 2024
College of Information Engineering, Yancheng Teachers University, Yancheng, 224002, China.
Incremental broad learning system (IBLS) is an effective and efficient incremental learning method based on broad learning paradigm. Owing to its streamlined network architecture and flexible dynamic update scheme, IBLS can achieve rapid incremental reconstruction on the basis of the previous model without the entire retraining from scratch, which enables it adept at handling streaming data. However, two prominent deficiencies still persist in IBLS and constrain its further promotion in large-scale data stream scenarios.
View Article and Find Full Text PDFThe role of government in helping SMEs to access finance: An evolutionary game modeling and simulation approach.
PLoS One
December 2024
School of Intellectual Property, Jiangsu University, Zhengjiang, Jiangsu Province, China.
Purpose: This study aims to delineate the operating system of a strategic game model involving three core financial actors-government, banks, and guarantee institutions, with a focus on their collective impact on system evolution towards sustainable SME financing.
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Results: The simulation experiments reveal the critical role of quality risk information and responsible actor behavior in maintaining low default rates and fostering a sustainable financial system.
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