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Predicting autosomal dominant polycystic kidney disease progression: review of promising Serum and urine biomarkers.
Front Pediatr
November 2023
Division of Nephrology, Dialysis and Transplantation, Department of Pediatrics, University Hospital Centre Zagreb, Zagreb, Croatia.
Autosomal dominant polycystic kidney disease (ADPKD) is one of the leading causes of end-stage renal disease. In spite of the recent tremendous progress in the understanding of ADPKD pathogenesis, the molecular mechanisms of the disease remain incompletely understood. Considering emerging new targeted therapies for ADPKD, it has become crucial to disclose easily measurable and widely available biomarkers for identifying patients with future rapid disease progression.
View Article and Find Full Text PDFImmediate drop of urine osmolality upon tolvaptan initiation predicts impact on renal prognosis in patients with ADPKD.
Nephrol Dial Transplant
May 2024
Department of Nephrology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, Japan.
Background: Tolvaptan, a vasopressin V2 receptor antagonist, is used for treating autosomal dominant polycystic kidney disease (ADPKD). We focused on changes in urinary osmolality (U-Osm) after tolvaptan initiation to determine whether they were associated with the therapeutic response to tolvaptan.
Methods: This was a single-centre, prospective, observational cohort study.
Evaluation of simple diagnostic parameters in acute kidney injury in hospitalized patients-diagnostic recommendations for non-nephrologists.
Intern Emerg Med
September 2023
Department of Internal Medicine, Nephrology & Intensive Care Medicine, Phillips University, Baldinger Straße 1, 35043, Marburg, Germany.
Acute kidney injury (AKI) is very common in hospitalized patients, affecting patient's mortality and morbidity. Major causes are prerenal AKI and acute tubular necrosis (ATN). Even though a variety of parameters/indices exist, their reliability and practicability are controversial: in fact, there is a need for a simple diagnostic approach for AKI in in-patients with parameters easily obtained in any hospital.
View Article and Find Full Text PDFUrine-to-plasma creatinine ratio and fractional excretion of urea performance in acute-on-chronic kidney disease patients.
J Nephrol
December 2023
Department of Nephrology, University Hospital of Reims, Reims, France.
The urine-to-plasma urea concentration ratio is associated with eGFR and eGFR decline over time in a population cohort.
Nephrol Dial Transplant
December 2023
Department of Epidemiology and Health Systems (DESS), University Center for General Medicine and Public Health (UNISANTE), Lausanne, Switzerland.
Background: Evaluation of renal function and of factors associated with its decline are important public health issues. Besides markers of glomerular function [e.g.
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