AI Article Synopsis
- Charcot neuroarthropathy (CN) involves complex mechanisms, primarily centered around inflammation and disruptions in bone remodeling that lead to bone damage.
- There is a potential connection between inflammation in CN and rapid improvements in long-term high blood sugar levels, which can trigger a specific type of neuropathy called treatment-induced neuropathy of diabetes (TIND).
- This text aims to enhance understanding of the unclear mechanisms behind CN's pathophysiology.
Article Abstract
The pathophysiology of Charcot neuroarthropathy (CN) includes a number of gray areas, particularly regarding the onset of inflammation which induces the disruption of the bone remodeling factor responsible for the onset of bone lysis. This clinical insight highlights a potential link between this inflammation and the rapid correction of chronic hyperglycemia (Dardari et al., 2022), which is known to be responsible for a particular type of neuropathy known as treatment-induced neuropathy of diabetes (TIND). Our description makes an additional contribution to shed light on the mysterious physiopathology of CN.
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| http://dx.doi.org/10.1016/j.tem.2022.12.003 | DOI Listing |
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