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derived outer membrane vesicles mediated bacterial virulence, antibiotic resistance, host immune responses and clinical applications.
Virulence
December 2025
Henan International Joint Laboratory of Children's Infectious Diseases, Department of Neonatology, Henan Province Engineering Research Center of Diagnosis and Treatment of Pediatric Infection and Critical Care, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, China.
is a gram-negative pathogen that can cause multiple diseases including sepsis, urinary tract infections, and pneumonia. The escalating detections of hypervirulent and antibiotic-resistant isolates are giving rise to growing public concerns. Outer membrane vesicles (OMVs) are spherical vesicles containing bioactive substances including lipopolysaccharides, peptidoglycans, periplasmic and cytoplasmic proteins, and nucleic acids.
View Article and Find Full Text PDFClinical and Electromyographic Characteristics of Pediatric Laryngeal Dyskinesia.
Otolaryngol Head Neck Surg
January 2025
Divisions of Pediatric Surgery and Otolaryngology-Head and Neck Surgery, The Stollery Children's Hospital and University of Alberta Hospital, Edmonton, Alberta, Canada.
Objective: To report the clinical and laryngeal electromyographic (LEMG) parameters of children with laryngeal dyskinesia (LD) and its prevalence among laryngeal mobility disorder (LMD) requiring full airway examination.
Study Design: Retrospective uncontrolled study.
Setting: Tertiary pediatric center.
Epithelial-to-mesenchymal transition and live cell extrusion contribute to measles virus release from human airway epithelia.
J Virol
January 2025
Microbiology and Immunology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA.
Measles virus (MeV) is a highly contagious respiratory virus transmitted via aerosols. To understand how MeV exits the airways of an infected host, we use unpassaged primary cultures of human airway epithelial cells (HAE). MeV typically remains cell-associated in HAE and forms foci of infection, termed infectious centers, by directly spreading cell-to-cell.
View Article and Find Full Text PDFImpact of Nurse Staffing Levels on Patient Fall Rates: A Retrospective Cross-Sectional Study in General Wards in Japan.
Healthcare (Basel)
January 2025
Department of Clinical Data Management and Research, Clinical Research Center, National Hospital Organization Headquarters, 2-5-11 Higashigaoka, Meguro-ku, Tokyo 152-8621, Japan.
: Falls are common adverse events among hospitalized patients, affecting outcomes and placing a financial burden on patients and hospitals. This study investigated the relationship between nurse staffing/workload and patient falls during hospitalization. : The patients studied were hospitalized in the general wards (excluding pediatrics and obstetrics/gynecology) of 11 National Hospital Organization institutions between April 2019 and March 2020.
View Article and Find Full Text PDFJob Demands and Resources Shape the Risk of Burnout in Italian Child Neuropsychiatrists.
Healthcare (Basel)
December 2024
Department of Brain and Behavioral Sciences, University of Pavia, 27100 Pavia, Italy.
To evaluate the influence of job demands and resources on burnout risk among Italian pediatric neuropsychiatrists. This cross-sectional study was conducted between December 2023 and February 2024 and involved Italian pediatric neuropsychiatrists. The study applied the Job Demands-Resources (JD-R) model to assess the impact of job demands (such as work-family conflict, time pressure, and job uncertainty) and job resources (like organizational support and perceived job meaning) on burnout.
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