AI Article Synopsis
- A study was conducted to explore the effectiveness of F-GP1 PET/CT angiography in detecting thrombus formation in coronary arteries of patients with and without acute myocardial infarction.
- Out of 99 patients, 80% of those with myocardial infarction showed significant uptake of the F-GP1 radiotracer, suggesting the presence of thrombosis, although some false negatives were noted.
- This noninvasive imaging technique has the potential to enhance the diagnosis and treatment strategies for myocardial infarction by clearly identifying thrombus locations within the heart.
Article Abstract
Background: The diagnosis and management of myocardial infarction are increasingly complex, and establishing the presence of intracoronary thrombosis has major implications for both the classification and treatment of myocardial infarction.
Objectives: The aim of this study was to investigate whether positron emission tomographic (PET) and computed tomographic (CT) imaging could noninvasively detect in vivo thrombus formation in human coronary arteries using a novel glycoprotein IIb/IIIa receptor antagonist-based radiotracer, F-GP1.
Methods: In a single-center observational case-control study, patients with or without acute myocardial infarction underwent coronary F-GP1 PET/CT angiography. Coronary artery F-GP1 uptake was assessed visually and quantified using maximum target-to-background ratios.
Results: F-GP1 PET/CT angiography was performed in 49 patients with and 50 patients without acute myocardial infarction (mean age: 61 ± 9 years, 75% men). Coronary F-GP1 uptake was apparent in 39 of the 49 culprit lesions (80%) in patients with acute myocardial infarction. False negative results appeared to relate to time delays to scan performance and low thrombus burden in small-caliber distal arteries. On multivariable regression analysis, culprit vessel status was the only independent variable associated with higher F-GP1 uptake. Extracoronary cardiac F-GP1 findings included a high frequency of infarct-related intramyocardial uptake (35%) as well as left ventricular (8%) or left atrial (2%) thrombus.
Conclusions: Coronary F-GP1 PET/CT angiography is the first noninvasive selective technique to identify in vivo coronary thrombosis in patients with acute myocardial infarction. This novel approach can further define the role and location of thrombosis within the heart and has the potential to inform the diagnosis, management, and treatment of patients with acute myocardial infarction. (In-Vivo Thrombus Imaging With F-GP1, a Novel Platelet PET Radiotracer [iThrombus]; NCT03943966).
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| http://dx.doi.org/10.1016/j.jcmg.2022.10.002 | DOI Listing |
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