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Randomized Comparison of Novel Low-Dose Sirolimus-Eluting Biodegradable Polymer Stent vs Second-Generation DES: TARGET-IV NA Trial.
J Am Coll Cardiol
October 2024
Clinical Trial Center, Cardiovascular Research Foundation, New York, New York, USA; NewYork-Presbyterian Hospital/Columbia University Medical Center, New York, New York, USA.
Background: Drug-eluting stents (DESs) with controlled antiproliferative drug release reduce restenosis risk, but durable polymers can delay healing and inhibit reendothelialization. The Firehawk biodegradable polymer sirolimus-eluting stent (BP-SES) has a fully biodegradable sirolimus-containing polymer coating localized to recessed abluminal grooves on the stent surface and delivers roughly one-third the drug dose of other DESs.
Objectives: We report the primary results of the TARGET-IV NA (Firehawk Rapamycin Target Eluting Coronary Stent North American Trial) randomized controlled trial comparing clinical outcomes with BP-SES vs currently used second-generation DESs.
Recycling and Reutilization of Metals Aided by Deep Eutectic Solvents: from NMC Cathodes of Spent Li-ion Batteries to Electrolytes for Supercapacitors.
ChemSusChem
July 2024
Instituto de Ciencia de Materiales de Madrid (ICMM), Consejo Superior de Investigaciones Científicas (CSIC), 28049, Madrid, Spain.
With the rapidly increasing demand for lithium ion batteries (LIBs), recycling the metals found in spent cathodes is mandatory to both alleviate shortages resulting from the mining of natural metal ores and manage the disposal of spent LIBs. The use of deep eutectic solvents (DESs) for metals recovery from spent cathodes of LIBs (e. g.
View Article and Find Full Text PDFPorous phenolic resin regulated by alcohol-based deep eutectic solvent for selective extraction and separation of tanshinones from Salvia miltiorrhiza.
Talanta
April 2024
School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, China. Electronic address:
Deep eutectic solvents (DES), regarded as promising green solvents, have gained attention due to their distinctive properties, particularly in analytical chemistry. While the use of DES in solvent extraction and separation has been extensively studied, its application in the synthesis of adsorbents has just begun. Phenolic resin, with its polyhydroxy structure and stable spherical morphology, could serve as an effective as adsorbents for enrichment of active ingredients in herbal medicine.
View Article and Find Full Text PDFIn-stent restenosis after percutaneous coronary intervention: emerging knowledge on biological pathways.
Eur Heart J Open
September 2023
Department of Surgical, Medical and Molecular Pathology and of Critical Sciences, University of Pisa, Lungarno Antonio Pacinotti 43, 56126 Pisa, Italy.
Article Synopsis
- Percutaneous coronary intervention (PCI) has improved over 40 years, yet in-stent restenosis (ISR) remains a significant complication, affecting a large patient population despite reduced rates due to advancements like drug-eluting stents.
- ISR is influenced by various factors, including patient genetics and the characteristics of the stent and procedure, and involves biological responses to the mechanical trauma of PCI that can lead to either healing or problematic vessel growth.
- Understanding the molecular pathways underlying ISR is vital for developing effective treatments, with new strategies such as EPC-capturing stents showing promise in improving stent healing and reducing complications like stent thrombosis.
Investigating the effect of drug release on in-stent restenosis: A hybrid continuum - agent-based modelling approach.
Comput Methods Programs Biomed
November 2023
Division of Biomedical Engineering, University of Glasgow, Glasgow, UK. Electronic address:
Background And Objective: In-stent restenosis (ISR) following percutaneous coronary intervention with drug-eluting stent (DES) implantation remains an unresolved issue, with ISR rates up to 10%. The use of antiproliferative drugs on DESs has significantly reduced ISR. However, a complete knowledge of the mechanobiological processes underlying ISR is still lacking.
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