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New chemical structures and liver-protective activity of the diterpenoids from Callicarpa rubella. | LitMetric

AI Article Synopsis

Article Abstract

Callicarpa rubella is a characteristic folk herb in the genus Callicarpa, and has abundant ethnobotanical usage as indigenous medicine in Lingnan area of P. R. China. However, the phytochemical and pharmacological properties of C. rubella was rarely investigated. Now, three new diterpenoids, named rubellapene A-C (1-3), along with five known analogues (4-8), were isolated from C. rubella. Their structures were determined by spectroscopic methods, quantum chemical electronic circular dichroism calculations and single-crystal X-ray diffraction analysis. Notably, the norditerpenoids C of clerodane type (rubellapene B) was rarely found in the genus Callicarpa. The liver protective effects of all of the isolates (1-8) were evaluated by the changes of cell viability and transaminase content of AST and ALT in HO-induced BRL cells. Compound 1, 3-8 exhibited that potent liver protective effects at different levels.

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Source
http://dx.doi.org/10.1016/j.fitote.2022.105394DOI Listing

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